Bus Tickets from Louisville to Knoxville, TN

Previously seen trips

Next departures for Louisville to Knoxville on November 2
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
    		Louisville, KY
    		Knoxville Bus StationNo tags
    Greyhound
      		Louisville, KY
      		Knoxville Bus StationNo tags
      Greyhound
        		Louisville, KY
        		Knoxville Bus StationNo tags
        Greyhound
          		Louisville, KY
          		Knoxville Bus StationNo tags
          Greyhound
            		Louisville, KY
            		Knoxville Bus StationNo tags

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            Get from Louisville to Knoxville

            This route is served by bus only

            The journey takes about 14 hours 5 minutes, and with fares starting at just US$50, it presents an excellent value for a comfortable ride.

            2bus per day
            14h 5mAverage Duration
            302 kmDistance
            8kgCO₂ emissions

            Bus Louisville to Knoxville, TN: Trip Overview

            Average Ticket PriceUS$97
            Average Bus Trip Duration14h 5m
            Number of daily buses2
            Earliest bus departure2:50am
            Distance301 km
            Latest bus departure10:55pm

            Louisville to Knoxville Bus

            Busbud helps you find a bus from Louisville to Knoxville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            We make sure you can find a bus service from Louisville to Knoxville from the most reliable bus companies operating this trip.

            Discover how much the bus trip from Louisville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions on the trip Louisville - Knoxville, TN

            1. What is the distance between Louisville and Knoxville?

              The distance between Louisville and Knoxville is around 304 km (188 miles).

            2. What are the departure and arrival locations for buses traveling from Louisville to Knoxville?

              Buses traveling this route start their trip at Louisville Greyhound Bus Station, in Louisville, and end it at 100 Kirkwood St, in Knoxville.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10-31
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            11-01
            US$43
            Today
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            11-03
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            11-04
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            busbud logoThe cheapest trip from Louisville to Knoxville, TN was searched and found on Nov 1, 2025 with a price of US$43

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Louisville to Knoxville, TN, as early as possible.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Louisville and Knoxville!

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from Louisville to Knoxville, get comfy and count the stars.

            Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Louisville to Knoxville will emit less CO2 than a car or an airplane.

            Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Louisville to Knoxville.

            Did you know?

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

            Will you be returning to Louisville by bus?

            Bus from Knoxville, TN to Louisville

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