Bus from Santiago, CL to Santa Cruz, CL: Tickets & Timetables

Next bus departures

Next departures from Santiago to Santa Cruz on 17 March
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Flixbus ChileBus
Terminal San Borja
Terminal de Buses Santa CruzCheapest
AndimarBus
San Bernardo, Santiago (Cruce Colon)
Terminal de Buses Santa CruzFastest
Buses Jet SurBus
Terminal Sur
Terminal Santa CruzNo tags
Buses TranSantinBus
Terminal Sur
Terminal Santa CruzNo tags
Flixbus ChileBus
Terminal San Borja
Terminal de Buses Santa CruzNo tags

Last refresh of the prices: Last Wednesday at 04:22 -03.

Get from Santiago to Santa Cruz

This route is served by bus only

The journey takes about 2 hours 40 minutes, and with fares starting at just €6, it presents an excellent value for a comfortable ride.

40bus per day
2h 40mAverage duration
132 kmDistance
3kgCO₂ emissions

Frequently asked questions about travelling by bus from Santiago, CL to Santa Cruz, CL

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

  1. How much is the bus ticket from Santiago to Santa Cruz?

    The cheapest coach tickets from Santiago to Santa Cruz start from €6. The average price for this route is around €7. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus journey from Santiago to Santa Cruz?

    The average bus journey time from Santiago to Santa Cruz is 2h 40m, covering a distance of 132 km. The fastest bus can take you there in 2h 25m and is operated by Buses Andimar.

  3. Which bus companies service the Santiago to Santa Cruz route?

    Several major bus companies operate on this route with 40 buses available per day, including services from Buses Andimar, buses TranSantin, FlixBus, Buses Jet Sur, Condor Bus.

  4. What is the earliest and latest departure time for the bus from Santiago to Santa Cruz?

    The earliest bus departs from Santiago to Santa Cruz at 05:30. And the latest bus departs at 21:14.

  5. What are the CO₂ emissions for the bus trip from Santiago to Santa Cruz?

    A bus journey from Santiago to Santa Cruz produces an estimated 3 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.

  6. Which is the best bus company from Santiago to Santa Cruz?

    According to Busbud customers, the highest-rated bus company on this route is buses TranSantin, with an average rating of 4.1 out of 5 stars based on 313 reviews.

  7. Which company has the best Wi-Fi from Santiago to Santa Cruz?

    Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

  8. Which bus company offers the most punctual service from Santiago to Santa Cruz?

    According to Busbud traveller reviews, the most punctual bus company on this route is buses TranSantin, with a punctuality rating of 4.3 out of 5 stars.

  9. Which bus company has the cleanest buses from Santiago to Santa Cruz?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is buses TranSantin, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/03
€1
13/03
€1
Today
€1
15/03
€6
16/03
€1
17/03
€6
18/03
€6
19/03
€1
busbud logoThe cheapest trip from Santiago, CL to Santa Cruz, CL was searched and found on 14 Mar 2026 with a price of €1

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Santa Cruz, CL as early as possible.

You can expect to pay from €1 to €11 for a bus ticket from Santiago, CL to Santa Cruz, CL based on the last 2 days. You can expect to find the cheapest price for the trip at €1, which is on 2026-03-19.

Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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