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Find the cheapest bus tickets from Santiago to Guayaquil

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Santiago to Guayaquil Buses

With Busbud, comparing and booking tickets for a bus from Santiago to Guayaquil is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Guayaquil from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to Guayaquil will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Stations & Stops

Need a bus leaving from Santiago? Your starting point is at Terminal Sur, Terrapuerto Los Heroes, San Borja, Pajaritos, Omnium, Terminal ETM, Cruce Colon, Antonio Bellet, Arturo Alessandri or Bellavista.

If you're onboard a bus traveling to Guayaquil, you can get hop off at Terminal Terrestre, BOL-GUAYAQUIL, Guayaquil, GUAYAQUIL or Terminal Aéreo Internacional.

Santiago to Guayaquil Route Map

Santiago to Guayaquil Route Map

Frequently asked questions for your trip Santiago - Guayaquil

What are the departure and arrival stations when taking the bus from Santiago to Guayaquil?

Buses traveling between Santiago and Guayaquil leave from Terminal Sur or Terrapuerto Los Heroes and arrive at Terminal Terrestre, BOL-GUAYAQUIL, Guayaquil.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Santiago to Guayaquil.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Guayaquil, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Santiago to Guayaquil will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Guayaquil.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Santiago by bus?

If you are looking for the return bus journey, check out buses from Guayaquil to Santiago.

Popular Buses Connecting Santiago

Popular Buses Connecting Guayaquil

Popular routes in this country

Why choose Busbud?

The Best Way To Book Bus Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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