Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Depew Station | Greyhound Amtrak Station | CheapestFastest |
Last refresh of the prices: Today at 13:05 EDT.
Compare 2 ways to travel from Buffalo to Indianapolis
Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 19 hours 5 minutes and with fares starting at just £54, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Buffalo, NY and Indianapolis?
Train Companies
Based on 5776 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the Wi‑Fi. Amtrak ticket prices on this trip start at £132
Frequently asked questions about travelling from Buffalo, NY to Indianapolis by train
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much does a train ticket cost from Buffalo to Indianapolis?
The cheapest train tickets from Buffalo to Indianapolis start from £132. The average price for this train route is around £180. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the train journey from Buffalo to Indianapolis?
The average train journey time from Buffalo to Indianapolis is 23h 10m, covering a distance of 442 miles. The fastest train gets you there in 23h 10m and is operated by Amtrak.
Which train operators serve the Buffalo to Indianapolis route?
Several major train operators run on this route with 1 trains available per day.
What are the earliest and latest departure times for the train from Buffalo to Indianapolis?
The earliest train from Buffalo to Indianapolis departs at 00:39. And the latest train departs at 00:39.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to Indianapolis was searched and found on 31 Mar 2026 with a price of £75To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to Indianapolis as early as possible.
You can expect to pay from £75 to £620 for a train ticket from Buffalo, NY to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at £75, which is on 2026-03-31.
