Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Greenville Station | Chicago (Union Station), IL | Cheapest | ||||
| Train | Greenville Station | Chicago (Union Station), IL | Fastest | ||||
| Train | Greenville Station | Chicago (Union Station), IL | No tags | ||||
| Train | Greenville Station | Chicago (Union Station), IL | No tags |
Last refresh of the prices: Yesterday at 06:34 EST.
Compare 2 ways to travel from Greenville to Chicago
Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 21 hours 30 minutes and with fares starting at just £74, it presents an excellent value for a comfortable ride.
Train Companies
Based on 5750 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the Wi‑Fi. Amtrak ticket prices on this trip start at £133
Frequently asked questions about travelling from Greenville, SC to Chicago by train
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much does a train ticket cost from Greenville to Chicago?
The cheapest train tickets from Greenville to Chicago start from £133. The average price for this train route is around £226. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the train journey from Greenville to Chicago?
The average train journey time from Greenville to Chicago is 1d 7h, covering a distance of 561 miles. The fastest train gets you there in 1d 7h and is operated by Amtrak.
Which train operators serve the Greenville to Chicago route?
Several major train operators run on this route with 1 trains available per day.
What are the earliest and latest departure times for the train from Greenville to Chicago?
The earliest train from Greenville to Chicago departs at 02:23. And the latest train departs at 02:23.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Chicago was searched and found on 28 Jan 2026 with a price of £127To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Greenville, SC to Chicago as early as possible.
You can expect to pay from £127 to £741 for a train ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £127, which is on 2026-01-28.
