Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Metroplaza Guatemala | Fertica Santa Ana | CheapestFastest | |||||
| Hotel las Americas | Gasolinera Puma Los Naranjos | No tags | |||||
 | Holiday Inn Guatemala City | Gasolinera Puma | No tags | |||||
| Metroplaza Guatemala | Fertica Santa Ana | No tags | |||||
| Holiday Inn Guatemala City | Gasolinera Puma | No tags |
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Bus Guatemala City to Santa Ana, SV: Trip Overview
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Guatemala City to Santa Ana Bus
Busbud helps you find a bus from Guatemala City to Santa Ana. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Guatemala City to Santa Ana from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Santa Ana from Guatemala City, we help you find what you're looking for based on how much of a budget you have.
Frequently asked questions on the trip Guatemala City - Santa Ana, SV
How far is Santa Ana from Guatemala City by coach?
The journey from Guatemala City to Santa Ana by coach covers an approximate distance of 78 miles (126 km).
Is there a way to reach Santa Ana from Guatemala City without a car?
You can reach Santa Ana from Guatemala City by coach, as there are regular services between the two locations. Depending on your preferences, another alternative is to explore ridesharing trips.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Guatemala City to Santa Ana, SV was searched and found on 11 Oct 2025 with a price of US$35To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Guatemala City to Santa Ana, SV as early as possible.
You can expect to pay from US$35 to US$88 for a bus ticket from Guatemala City to Santa Ana, SV based on the last 2 days. You can expect to find the cheapest price for the trip at US$35, which is on 2025-10-14.
Usually Guatego will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Guatemala City and Santa Ana!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Guatemala City to Santa Ana, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Guatemala City to Santa Ana.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Guatemala City to Santa Ana.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Top travelled bus routes
Why choose Busbud?
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Popular Buses Connecting Guatemala City
Buses Leaving from Guatemala City
- Bus from Guatemala City to Izabal
- Coach Guatemala City - Puerto Barrios
- Bus Guatemala City - Ahuachapan
- Guatemala City - León
- Bus from Guatemala City to EL AMATILLO
- Coach Guatemala City - Tipitapa
- Bus Guatemala City - Chinandega
- Guatemala City - Esteli
- Bus from Guatemala City to Orotina
- Coach Guatemala City - Rivas
- Bus Guatemala City - Liberia
- Guatemala City - La Libertad
- Bus from Guatemala City to Sébaco
- Coach Guatemala City - San Miguel
- Bus Guatemala City - Ocotal
Buses Going to Guatemala City
- Bus from Managua to Guatemala City
- Coach Izabal - Guatemala City
- Bus Tipitapa - Guatemala City
- La Libertad - Guatemala City
- Bus from Esteli to Guatemala City
- Coach Ocotal - Guatemala City
- Bus La Union - Guatemala City
- Ahuachapan - Guatemala City
- Bus from San Isidro to Guatemala City
- Coach EL AMATILLO - Guatemala City
- Bus Sébaco - Guatemala City
- San Miguel - Guatemala City