How much is the bus ticket from Panama City to Chicago?

The cheapest coach tickets from Panama City to Chicago start from €119. The average price for this route is around €188. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus journey from Panama City to Chicago?

The average bus journey time from Panama City to Chicago is 1d 6h, covering a distance of 1311 km. The fastest bus can take you there in 1d 2h and is operated by Greyhound .

Which bus companies service the Panama City to Chicago route?

Several major bus companies operate on this route with 8 buses available per day.

What is the earliest and latest departure time for the bus from Panama City to Chicago?

The earliest bus departs from Panama City to Chicago at 07:30. And the latest bus departs at 21:40.

What are the CO₂ emissions for the bus trip from Panama City to Chicago?

A bus journey from Panama City to Chicago produces an estimated 33 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.

Bus Panama City to Chicago from €113 | Refundable Tickets

Next bus departures

Next departures from Panama City to Chicago on 29 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	21:40	Panama City Beach Station	1d 6h	04:10	Downtown Greyhound Station	CheapestFastest
	Bus	21:40	Panama City Beach Station	1d 10h	08:00	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	21:40	Panama City Beach Station	1d 7h	05:20	Chicago 95Th & Dan Ryan	No tags

Next departures from Panama City to Chicago on 30 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	21:40	Panama City Beach Station	1d 6h	04:10	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 3h	11:05	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 4h	11:30	Downtown Greyhound Station	No tags
	Bus	07:30	Panama City Beach Station	1d 6h	14:10	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:15	Panama City Beach Station	1d 9h	00:10	Downtown Greyhound Station	No tags

Next departures from Panama City to Chicago on 31 January
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	14:15	Panama City Beach Station	1d 9h	00:10	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 3h	11:05	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 4h	11:30	Downtown Greyhound Station	No tags
	Bus	21:40	Panama City Beach Station	1d 6h	04:10	Downtown Greyhound Station	No tags
	Bus	07:30	Panama City Beach Station	1d 6h	14:10	537-517 W. Jackson Blvd	No tags

Next departures from Panama City to Chicago on 1 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 4h	11:30	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 3h	11:05	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	14:15	Panama City Beach Station	1d 9h	00:10	Downtown Greyhound Station	No tags
	Bus	21:40	Panama City Beach Station	1d 6h	04:10	Downtown Greyhound Station	No tags
	Bus	07:30	Panama City Beach Station	1d 6h	14:10	537-517 W. Jackson Blvd	No tags

Next departures from Panama City to Chicago on 2 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	14:15	Panama City Beach Station	1d 9h	00:10	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 3h	11:05	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 4h	11:30	Downtown Greyhound Station	No tags
	Bus	21:40	Panama City Beach Station	1d 6h	04:10	Downtown Greyhound Station	No tags
	Bus	07:30	Panama City Beach Station	1d 6h	14:10	537-517 W. Jackson Blvd	No tags

Next departures from Panama City to Chicago on 3 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	21:40	Panama City Beach Station	1d 10h	08:20	Chicago 95Th & Dan Ryan	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 3h	11:05	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 4h	11:30	Downtown Greyhound Station	No tags
	Bus	21:40	Panama City Beach Station	1d 6h	04:10	Downtown Greyhound Station	No tags
	Bus	07:30	Panama City Beach Station	1d 6h	14:10	537-517 W. Jackson Blvd	No tags

Next departures from Panama City to Chicago on 4 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 3h	11:05	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	07:30	Panama City Beach Station	1d 4h	11:30	Downtown Greyhound Station	No tags
	Bus	21:40	Panama City Beach Station	1d 6h	04:10	Downtown Greyhound Station	No tags
	Bus	07:30	Panama City Beach Station	1d 6h	14:10	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	21:40	Panama City Beach Station	1d 7h	05:20	Chicago 95Th & Dan Ryan	No tags

Last refresh of the prices: Last Sunday at 05:28 CST.

Get from Panama City to Chicago

This route is served by bus only

The journey takes about 1 day, 6 hours 40 minutes, and with fares starting at just €119, it presents an excellent value for a comfortable ride.

8bus per day

1d 6hAverage duration

1311 kmDistance

33kgCO₂ emissions

Where are the popular stops in Panama City and Chicago?

Stops in Panama City

A
Panama City Greyhound Bus Station
917 Harrison Ave, Panama City, FL 32401

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/587,518 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wi‑Fi2.5

Based on 87518 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at €126

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling by bus from Panama City, US to Chicago

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

How much is the bus ticket from Panama City to Chicago?
The cheapest coach tickets from Panama City to Chicago start from €119. The average price for this route is around €188. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Panama City to Chicago?
The average bus journey time from Panama City to Chicago is 1d 6h, covering a distance of 1311 km. The fastest bus can take you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Panama City to Chicago route?
Several major bus companies operate on this route with 8 buses available per day.
What is the earliest and latest departure time for the bus from Panama City to Chicago?
The earliest bus departs from Panama City to Chicago at 07:30. And the latest bus departs at 21:40.
What are the CO₂ emissions for the bus trip from Panama City to Chicago?
A bus journey from Panama City to Chicago produces an estimated 33 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

27/01

€182

28/01

€183

Today

€123

30/01

€120

31/01

€171

01/02

€119

02/02

€113

03/02

€168

The cheapest trip from Panama City, US to Chicago was searched and found on 2 Feb 2026 with a price of €113

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Chicago as early as possible.

You can expect to pay from €113 to €192 for a bus ticket from Panama City, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at €113, which is on 2026-02-02.