How much is the bus ticket from Panama City to Chicago?

The cheapest bus tickets from Panama City to Chicago start from $139. The average price for this route is around $219. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Panama City to Chicago?

The average bus trip duration from Panama City to Chicago is 1d 6h, covering a distance of 813 miles (1311 km). The quickest bus can get you there in 1d 2h and is operated by Greyhound .

Which bus companies service the Panama City to Chicago route?

Several major bus companies operate on this route with 8 buses available per day.

What is the earliest and latest departure time for the bus from Panama City to Chicago?

The earliest bus departs from Panama City to Chicago at 7:30am. And the latest bus departs at 9:40pm.

What are the CO₂ emissions for the bus trip from Panama City to Chicago?

A bus trip from Panama City to Chicago generates an estimated 33 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Bus Panama City to Chicago from $139 | Refundable Tickets

Next bus departures

Next departures for Panama City to Chicago on January 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	9:40pm	Panama City Beach Station	1d 10h	8:20am	Chicago 95Th & Dan Ryan	Cheapest
	Bus	9:40pm	Panama City Beach Station	1d 6h	4:10am	Downtown Greyhound Station	Fastest
	Bus	9:40pm	Panama City Beach Station	1d 10h	8:00am	537-517 W. Jackson Blvd	No tags

Next departures for Panama City to Chicago on January 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	9:40pm	Panama City Beach Station	1d 7h	5:20am	Chicago 95Th & Dan Ryan	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	7:30am	Panama City Beach Station	1d 3h	11:05am	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	7:30am	Panama City Beach Station	1d 4h	11:30am	Downtown Greyhound Station	No tags
	Bus	9:40pm	Panama City Beach Station	1d 6h	4:10am	Downtown Greyhound Station	No tags
	Bus	7:30am	Panama City Beach Station	1d 6h	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Panama City to Chicago on January 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	9:40pm	Panama City Beach Station	1d 6h	4:10am	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	7:30am	Panama City Beach Station	1d 3h	11:05am	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	7:30am	Panama City Beach Station	1d 4h	11:30am	Downtown Greyhound Station	No tags
	Bus	7:30am	Panama City Beach Station	1d 6h	2:10pm	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:15pm	Panama City Beach Station	1d 9h	12:10am	Downtown Greyhound Station	No tags

Next departures for Panama City to Chicago on January 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	9:40pm	Panama City Beach Station	1d 6h	4:10am	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	7:30am	Panama City Beach Station	1d 3h	11:05am	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	7:30am	Panama City Beach Station	1d 4h	11:30am	Downtown Greyhound Station	No tags
	Bus	7:30am	Panama City Beach Station	1d 6h	2:10pm	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	2:15pm	Panama City Beach Station	1d 9h	12:10am	Downtown Greyhound Station	No tags

Next departures for Panama City to Chicago on January 31
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	2:15pm	Panama City Beach Station	1d 9h	12:10am	Downtown Greyhound Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	7:30am	Panama City Beach Station	1d 3h	11:05am	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	7:30am	Panama City Beach Station	1d 4h	11:30am	Downtown Greyhound Station	No tags
	Bus	9:40pm	Panama City Beach Station	1d 6h	4:10am	Downtown Greyhound Station	No tags
	Bus	7:30am	Panama City Beach Station	1d 6h	2:10pm	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Last Saturday at 4:32 PM CST.

Get from Panama City to Chicago

This route is served by bus only

The journey takes about 1 day, 6 hours 40 minutes and with fares starting at just $139, it presents an excellent value for a comfortable ride.

8bus per day

1d 6hAverage Duration

813 milesDistance

33kgCO₂ emissions

Where are the popular stops in Panama City and Chicago?

Stops in Panama City

A
Panama City Greyhound Bus Station
917 Harrison Ave, Panama City, FL 32401

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/587,517 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Panama City, US to Chicago by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Panama City to Chicago?
The cheapest bus tickets from Panama City to Chicago start from $139. The average price for this route is around $219. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Panama City to Chicago?
The average bus trip duration from Panama City to Chicago is 1d 6h, covering a distance of 813 miles (1311 km). The quickest bus can get you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Panama City to Chicago route?
Several major bus companies operate on this route with 8 buses available per day.
What is the earliest and latest departure time for the bus from Panama City to Chicago?
The earliest bus departs from Panama City to Chicago at 7:30am. And the latest bus departs at 9:40pm.
What are the CO₂ emissions for the bus trip from Panama City to Chicago?
A bus trip from Panama City to Chicago generates an estimated 33 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/25

No data

01/26

$152

Today

$211

01/28

$213

01/29

$143

01/30

$139

01/31

$199

02/01

No data

The cheapest trip from Panama City, US to Chicago was searched and found on Jan 30, 2026 with a price of $139

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Chicago, as early as possible.

You can expect to pay from $139 to $231 for a bus ticket from Panama City, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $139 which is on 2026-01-30.