Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Syracuse (Regional Transportation Center) | Florence, SC | CheapestFastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Syracuse (Regional Transportation Center) | Bus station | No tags | ||||
 | Bus | Syracuse (Regional Transportation Center) | Bus station | No tags |
Last refresh of the prices: Last Thursday at 19:06 EDT.
Compare 2 ways to travel from Syracuse to Florence
Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 21 hours 35 minutes and with fares starting at just MX$1,716, it presents an excellent value for a comfortable ride.
Bus stations and stops in Syracuse and Florence
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210 - D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Florence
- A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA - B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Based on 88031 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at MX$1,882
Frequently asked questions about travelling by bus from Syracuse, US to Florence, SC, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Syracuse to Florence?
The cheapest coach tickets from Syracuse to Florence start from MX$1,716. The average price for this route is around MX$2,286. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Syracuse to Florence?
The average bus journey time from Syracuse to Florence is 21h 35m, covering a distance of 1036 km. The fastest bus can take you there in 21h 35m and is operated by Greyhound.
Which bus companies service the Syracuse to Florence route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Syracuse to Florence?
The earliest bus departs from Syracuse to Florence at 09:25. And the latest bus departs at 21:00.
What are the CO₂ emissions for the bus trip from Syracuse to Florence?
A bus journey from Syracuse to Florence produces an estimated 25.896749999999997 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Florence, SC, US was searched and found on 12 Aug 2026 with a price of MX$1,756To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Florence, SC, US as early as possible.
You can expect to pay from MX$1,756 to MX$4,567 for a bus ticket from Syracuse, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at MX$1,756, which is on 2026-08-12.
What's the cheapest way to go from Syracuse, US to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
