Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus
| Syracuse (Regional Transportation Center) | Florence, SC | Cheapest | ||||
 | Bus
| Syracuse (Regional Transportation Center) | Bus station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus
| Syracuse (Regional Transportation Center) | Bus station | No tags |
Last refresh of the prices: Yesterday at 3:34 PM EDT.
Compare 2 ways to go from Syracuse to Florence
Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 21 hours 55 minutes, and with fares starting at just THB 3,327, it presents an excellent value for a comfortable ride.
Bus stations and stops in Syracuse and Florence
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210 - D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Florence
- A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA - B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Based on 88163 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at THB 3,327
Frequently asked questions about travelling from Syracuse, US to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Syracuse to Florence?
The cheapest bus tickets from Syracuse to Florence start from THB 3,327. The average price for this route is around THB 4,452. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Florence?
The average bus travel time from Syracuse to Florence is 21h 55m, covering a distance of 1036 km. The quickest bus can get you there in 21h 35m and is operated by Greyhound.
Which bus companies service the Syracuse to Florence route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from Syracuse to Florence?
The earliest bus departs from Syracuse to Florence at 9:25am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Syracuse to Florence?
A bus trip from Syracuse to Florence generates an estimated 25.898649999999996 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Florence, SC, US was searched and found on Sep 21, 2026 with a price of THB 3,407To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Florence, SC, US, as early as possible.
You can expect to pay from THB 3,407 to THB 5,076 for a bus ticket from Syracuse, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at THB 4,497 which is on 2026-09-27.
What's the cheapest way to go from Syracuse, US to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
