Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Price and booking link |
|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Syracuse (Regional Transportation Center) | Bus station | ||||
FlixBus + Greyhound | Bus | Syracuse (Regional Transportation Center) | Florence, SC | ||||
Greyhound + FlixBus | Bus | Syracuse (Regional Transportation Center) | Florence, SC | ||||
Greyhound + FlixBus | Bus | Syracuse (Regional Transportation Center) | Bus station | ||||
FlixBus + Greyhound | Bus | Syracuse (Regional Transportation Center) | Bus station |
Compare 2 ways to go from Syracuse to Florence
Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 21 hours 35 minutes and with fares starting at just PLN 374, it presents an excellent value for a comfortable ride.
Bus stations and stops in Syracuse and Florence
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210 - D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Florence
- A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA - B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Syracuse, US to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Syracuse to Florence?
The cheapest bus tickets from Syracuse to Florence start from PLN 374. The average price for this route is around PLN 510. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Florence?
The average bus trip duration from Syracuse to Florence is 21h 35m, covering a distance of 643 miles (1036 km). The quickest bus can get you there in 21h 25m and is operated by Greyhound.
Which bus companies service the Syracuse to Florence route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Syracuse to Florence?
The earliest bus departs from Syracuse to Florence at 9:25am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Syracuse to Florence?
A bus trip from Syracuse to Florence generates an estimated 25.895925 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Florence, SC, US was searched and found on Aug 7, 2026 with a price of PLN 414To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Florence, SC, US, as early as possible.
You can expect to pay from PLN 414 to PLN 488 for a bus ticket from Syracuse, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at PLN 414 which is on 2026-08-07.
What's the cheapest way to go from Syracuse, US to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
