- Syracuse to Florence buses
Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Syracuse (Regional Transportation Center) | Florence, SC | No tags | ||||
Greyhound + FlixBus | Bus | Syracuse (Regional Transportation Center) | Florence, SC | No tags | ||||
Greyhound + FlixBus | Bus | Syracuse (Regional Transportation Center) | Bus station | No tags | ||||
FlixBus + Greyhound | Bus | Syracuse (Regional Transportation Center) | Florence, SC | No tags | ||||
Greyhound + FlixBus | Bus | Syracuse (Regional Transportation Center) | Florence, SC | No tags |
Compare 2 ways to go from Syracuse to Florence
Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 20 hours 45 minutes and with fares starting at just $124, it presents an excellent value for a comfortable ride.
Where are the popular stops in Syracuse and Florence?
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Syracuse, US to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Syracuse to Florence?
The cheapest bus tickets from Syracuse to Florence start from $124. The average price for this route is around $190. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Florence?
The average bus trip duration from Syracuse to Florence is 20h 45m, covering a distance of 642 miles (1036 km). The quickest bus can get you there in 19h 30m and is operated by Greyhound.
Which bus companies service the Syracuse to Florence route?
Several major train operators operate on this route with 3 trains available per day.
What is the earliest and latest departure time for the bus from Syracuse to Florence?
The earliest bus departs from Syracuse to Florence at 9:25am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Syracuse to Florence?
A bus trip from Syracuse to Florence generates an estimated 26 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.






