Previously seen trips

Next departures for Syracuse to Florence on September 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location
Greyhound + FlixBus	Bus Wifi Toilet Power outlets	3:00pm	Syracuse (Regional Transportation Center)	21h 45m	12:45pm	Bus station
FlixBus + Greyhound	Bus Wifi Toilet Power outlets	9:00pm	Syracuse (Regional Transportation Center)	1d 8h	5:45am	Florence, SC
Greyhound + FlixBus	Bus Wifi Toilet Power outlets	9:25am	Syracuse (Regional Transportation Center)	20h 20m	5:45am	Florence, SC
Greyhound + FlixBus	Bus Wifi Toilet Power outlets	3:55pm	Syracuse (Regional Transportation Center)	20h 50m	12:45pm	Bus station
FlixBus + Greyhound	Bus Wifi Toilet Power outlets	3:55pm	Syracuse (Regional Transportation Center)	20h 50m	12:45pm	Bus station

Compare 2 ways to go from Syracuse to Florence

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 21 hours 55 minutes and with fares starting at just ¥15,759, it presents an excellent value for a comfortable ride.

3bus per day

21h 55mAverage Duration

643 milesDistance

26kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price¥15,759 - ¥37,789	Average Duration21h 55m	CO₂ emissions 26kg CO₂e
Train	Average Price¥47,805 - ¥49,476	Average Duration20h 8m	CO₂ emissions 94kg CO₂e

Bus stations and stops in Syracuse and Florence

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

Greyhound

3.5/588,163 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies:FlixBus, Greyhound, Futura, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit

Frequently asked questions about traveling from Syracuse, US to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Syracuse to Florence?
The cheapest bus tickets from Syracuse to Florence start from ¥15,759. The average price for this route is around ¥21,086. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Syracuse to Florence?
The average bus trip duration from Syracuse to Florence is 21h 55m, covering a distance of 643 miles (1036 km). The quickest bus can get you there in 21h 35m and is operated by Greyhound.
Which bus companies service the Syracuse to Florence route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Syracuse to Florence?
The earliest bus departs from Syracuse to Florence at 9:25am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Syracuse to Florence?
A bus trip from Syracuse to Florence generates an estimated 25.898649999999996 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

09/20

No data

09/21

¥16,136

Today

¥20,977

09/23

¥24,044

09/24

No data

09/25

No data

09/26

No data

09/27

¥21,300

The cheapest trip from Syracuse, US to Florence, SC, US was searched and found on Sep 21, 2026 with a price of ¥16,136

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Florence, SC, US, as early as possible.

You can expect to pay from ¥16,136 to ¥24,044 for a bus ticket from Syracuse, US to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at ¥21,300 which is on 2026-09-27.