Find coaches from Chicago to Panama City, US

Previously seen journeys

Next departures from Chicago to Panama City on 30 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Downtown Greyhound Station
Panama City Beach StationNo tags
Greyhound
Downtown Greyhound Station
Panama City Beach StationNo tags
Greyhound
537-517 W. Jackson Blvd
Panama City Beach StationNo tags
Greyhound + FlixBus
Chicago 95Th & Dan Ryan
Panama City Beach StationNo tags
Greyhound
Downtown Greyhound Station
Panama City Beach StationNo tags

Accepted payments

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Get from Chicago to Panama City

busbud logoThis route is served by bus only

The journey takes about 1 day, 4 hours 20 minutes, and with fares starting at just US$149, it presents an excellent value for a comfortable ride.

8bus per day
1d 4hAverage duration
1311 kmDistance
33kgCO₂ emissions

Bus Chicago to Panama City, US: Trip Overview

Average ticket priceUS$171
Average bus trip duration1d 4h
Number of daily buses8
Earliest bus departure00:30
Distance1310 km
Latest bus departure23:59

Chicago to Panama City Bus

With Busbud, comparing and booking tickets for a bus from Chicago to Panama City is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Chicago to Panama City will be provided by the most trusted bus companies.

Discover how much the bus trip from Chicago to Panama City will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Chicago - Panama City, US

  1. How much does a bus ticket from Chicago to Panama City cost?

    The bus ticket price from Chicago to Panama City starts at US$149. The best way to find cheap bus tickets from Chicago to Panama City is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Chicago to Panama City?

    The average travel time between Chicago and Panama City is around 1d 4h, although the fastest bus will take about 22h 35m. This is the time it takes to travel the 1314 km that separates the two cities.

  3. How many daily bus connections are there between Chicago and Panama City?

    The number of buses from Chicago to Panama City can differ depending on the day of the week. On average, there are 8 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Chicago to Panama City by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Chicago to Panama City?

    When taking the bus from Chicago to Panama City, you can travel comfortably and safely with Greyhound, FlixBus.

  5. What are the departure and arrival stations when taking the bus from Chicago to Panama City?

    Buses travelling between Chicago and Panama City leave from Downtown Greyhound Station or Chicago O'Hare International Airport and arrive at Panama City Greyhound Bus Station.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
No data
29/10
US$150
Today
No data
31/10
No data
01/11
No data
02/11
No data
03/11
No data
04/11
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busbud logoThe cheapest trip from Chicago to Panama City, US was searched and found on 29 Oct 2025 with a price of US$150

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Panama City, US as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Chicago to Panama City.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Chicago to Panama City, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Chicago to Panama City will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Chicago to Panama City, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Chicago by bus?

Bus from Panama City, US to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

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