Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Panama City Beach Station | Cheapest | ||||
 | Bus | Chicago 95Th & Dan Ryan | Panama City Beach Station | Fastest | ||||
| Bus | Downtown Greyhound Station | Panama City Beach Station | No tags | ||||
| Bus | 537-517 W. Jackson Blvd | Panama City Beach Station | No tags |
Last refresh of the prices: Yesterday at 16:19 CST.
Get from Chicago to Panama City
The journey takes about 1 day, 4 hours, and with fares starting at just £96, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and Panama City?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Panama City
- A
Panama City Greyhound Bus Station
917 Harrison Ave, Panama City, FL 32401
Compare bus companies
Frequently asked questions about travelling by bus from Chicago to Panama City, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Chicago to Panama City?
The cheapest coach tickets from Chicago to Panama City start from £96. The average price for this route is around £146. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Chicago to Panama City?
The average bus journey time from Chicago to Panama City is 1d 4h, covering a distance of 813 miles. The fastest bus can take you there in 23h 5m and is operated by Greyhound.
Which bus companies service the Chicago to Panama City route?
What is the earliest and latest departure time for the bus from Chicago to Panama City?
The earliest bus departs from Chicago to Panama City at 05:25. And the latest bus departs at 23:59.
What are the CO₂ emissions for the bus trip from Chicago to Panama City?
A bus journey from Chicago to Panama City produces an estimated 33 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Chicago to Panama City?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which company has the best Wi-Fi from Chicago to Panama City?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Chicago to Panama City?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Panama City?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Panama City, US was searched and found on 2 Dec 2025 with a price of £183To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Panama City, US as early as possible.
