Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Chicago 95Th & Dan Ryan | San Ysidro Bus terminal | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Downtown Greyhound Station | San Ysidro Bus terminal | Fastest | ||||
| Bus | Downtown Greyhound Station | San Ysidro Bus terminal | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 537-517 W. Jackson Blvd | San Ysidro Bus terminal | No tags | ||||
| Bus | 537-517 W. Jackson Blvd | San Ysidro Bus terminal | No tags |
Last refresh of the prices: Last Wednesday at 12:05 AM CST.
Get from Chicago to San Ysidro
The journey takes about 2 days, 6 hours, and with fares starting at just R 2 314, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and San Ysidro?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- B
Chicago O'Hare International Airport
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Based on 87500 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 2 339
Frequently asked questions about travelling from Chicago to San Ysidro, CA by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Chicago to San Ysidro?
The cheapest bus tickets from Chicago to San Ysidro start at R 2 314. The average price for this route is around R 4 415. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Chicago to San Ysidro?
The average bus journey time from Chicago to San Ysidro is 2d 6h, covering a distance of 2785 km. The fastest bus gets you there in 2d 5h and is operated by Greyhound.
Which bus companies service the Chicago to San Ysidro route?
Several major bus companies operate on this route with 9 buses available per day.
What is the earliest and latest departure time for the bus from Chicago to San Ysidro?
The earliest bus departs from Chicago to San Ysidro at 10:00. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Chicago to San Ysidro?
A bus trip from Chicago to San Ysidro produces an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to San Ysidro, CA was searched and found on 17 Jan 2026 with a price of R 3 463To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Ysidro, CA as early as possible.
You can expect to pay from R 3 463 to R 4 454 for a bus ticket from Chicago to San Ysidro, CA based on the last 2 days. You can expect to find the cheapest price for the trip at R 3 463, which is on 2026-01-17.
