Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Des Moines | Charlotte Bus Station | Cheapest | ||||
Jefferson Lines + Barons Bus Lines | Bus | Des Moines | Charlotte | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Charlotte Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Charlotte (Freedom Dr) | No tags |
Last refresh of the prices: Last Tuesday at 3:51 PM CST.
Get from Des Moines to Charlotte
The journey takes about 1 day, 7 hours 55 minutes, and with fares starting at just R 2 269, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Charlotte?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Charlotte
- A
Tornado & El Expreso Bus Company
4705 N. Tryon S, Charlotte, NC, USA - C
Charlotte Greyhound Bus Station
601 W Trade St , Charlotte, NC 28202 - D
Agencia El Salvador Bus Stop
4335 N Tryon St, Charlotte, NC 28213 - E
4127 Glenwood Dr
4127 Glenwood Dr, Charlotte, NC 28208 (Exxon Gas Station)
Compare bus companies
Based on 87521 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. Greyhound ticket prices on this trip start at R 2 269
Frequently asked questions about travelling from Des Moines to Charlotte, NC by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Des Moines to Charlotte?
The cheapest bus tickets from Des Moines to Charlotte start at R 2 269. The average price for this route is around R 3 785. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Des Moines to Charlotte?
The average bus journey time from Des Moines to Charlotte is 1d 7h, covering a distance of 1317 km. The fastest bus gets you there in 1d 5h and is operated by Greyhound.
Which bus companies service the Des Moines to Charlotte route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Des Moines to Charlotte?
The earliest bus departs from Des Moines to Charlotte at 05:30. And the latest bus departs at 23:45.
What are the CO₂ emissions for the bus trip from Des Moines to Charlotte?
A bus trip from Des Moines to Charlotte produces an estimated 33 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Charlotte, NC was searched and found on 04 Feb 2026 with a price of R 2 191To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Charlotte, NC as early as possible.
You can expect to pay from R 2 191 to R 2 191 for a bus ticket from Des Moines to Charlotte, NC based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 191, which is on 2026-02-06.
