Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Milwaukee Bus Station, St. Paul & N6th road. | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Milwaukee Mitchell MKE Airport | Fastest | ||||
 | Bus | Des Moines | Milwaukee Bus Station, St. Paul & N6th road. | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Des Moines | Goerke's Corners Park & Ride (Brookfield) | No tags | ||||
 | Bus | Des Moines | St. Paul & N5th | No tags |
Last refresh of the prices: Yesterday at 7:01 PM CST.
Get from Des Moines to Milwaukee
The journey takes about 12 hours 5 minutes, and with fares starting at just R 939, it presents an excellent value for a comfortable ride.
Where are the popular stops in Des Moines and Milwaukee?
Stops in Des Moines
- A
Jefferson/Trailways Depot
1501 2nd Ave North, Des Moines, IA 50314 - B
1514 East Grand Ave
1514 East Grand Avenue,, Des Moins, IA, 50316
Stops in Milwaukee
- A
Milwaukee Airport
- B433 W St Paul Ave, Milwaukee, WI 53203, USA
- C
S Cesar Chavez
1016 S Cesar E Chavez Dr, Milwaukee, WI 53204, USA
Compare bus companies
Frequently asked questions about travelling from Des Moines to Milwaukee by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Des Moines to Milwaukee?
The cheapest bus tickets from Des Moines to Milwaukee start at R 939. The average price for this route is around R 1 562. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Des Moines to Milwaukee?
The average bus journey time from Des Moines to Milwaukee is 12h 5m, covering a distance of 493 km. The fastest bus gets you there in 14h and is operated by Greyhound.
Which bus companies service the Des Moines to Milwaukee route?
Several major bus companies operate on this route with 5 buses available per day, including services from Jefferson Lines, Greyhound.
What is the earliest and latest departure time for the bus from Des Moines to Milwaukee?
The earliest bus departs from Des Moines to Milwaukee at 00:01. And the latest bus departs at 09:45.
What are the CO₂ emissions for the bus trip from Des Moines to Milwaukee?
A bus trip from Des Moines to Milwaukee produces an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Des Moines to Milwaukee?
According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 764 reviews.
Which bus company has the best Wi-Fi from Des Moines to Milwaukee?
Based on reviews on Busbud, the bus company Greyhound has the best Wi-Fi rating with a score of 2.4.
Which bus company offers the most punctual service from Des Moines to Milwaukee?
According to Busbud traveller reviews, the most punctual bus company on this route is Jefferson Lines, with a punctuality rating of 3.5 out of 5 stars.
Which bus company has the cleanest buses from Des Moines to Milwaukee?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Jefferson Lines, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Milwaukee was searched and found on 12 Jan 2026 with a price of R 1 028To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Milwaukee as early as possible.
You can expect to pay from R 1 028 to R 2 832 for a bus ticket from Des Moines to Milwaukee based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 028, which is on 2026-01-12.
Usually Jefferson Lines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
