Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Key Largo | Downtown Transit Center | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Key Largo | Indianapolis Bus Station | Fastest | ||||
 | Bus | Key Largo | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Key Largo | Downtown Transit Center | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Key Largo | Indianapolis Northeast | No tags |
Last refresh of the prices: Last Thursday at 4:14 AM EST.
Get from Key Largo to Indianapolis
The journey takes about 1 day, 9 hours 5 minutes, and with fares starting at just R 2 243, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87519 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained about the Wi-Fi. Greyhound ticket prices on this trip start at R 2 243
Frequently asked questions about travelling from Key Largo to Indianapolis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Key Largo to Indianapolis?
The cheapest bus tickets from Key Largo to Indianapolis start at R 2 243. The average price for this route is around R 2 293. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Key Largo to Indianapolis?
The average bus journey time from Key Largo to Indianapolis is 1d 9h, covering a distance of 1717 km. The fastest bus gets you there in 1d 3h and is operated by Greyhound.
Which bus companies service the Key Largo to Indianapolis route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Key Largo to Indianapolis?
The earliest bus departs from Key Largo to Indianapolis at 12:40. And the latest bus departs at 19:40.
What are the CO₂ emissions for the bus trip from Key Largo to Indianapolis?
A bus trip from Key Largo to Indianapolis produces an estimated 43 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Key Largo to Indianapolis was searched and found on 31 Jan 2026 with a price of R 2 158To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key Largo to Indianapolis as early as possible.
You can expect to pay from R 2 158 to R 2 249 for a bus ticket from Key Largo to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 174, which is on 2026-02-06.
