Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Bus Station, St. Paul & N6th road. | UCSD Health La Jolla Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Mitchell MKE Airport | UCSD Health La Jolla Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Bus Station, St. Paul & N6th road. | San Diego (Old Town-FlixBus) | No tags | ||||
 | Bus | Milwaukee Bus Station, St. Paul & N6th road. | Greyhound Bus Stop | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Milwaukee Bus Station, St. Paul & N6th road. | San Diego (Old Town-FlixBus) | No tags |
Last refresh of the prices: 01/23/2026 CST.
Compare 2 ways to travel from Milwaukee to San Diego
Among the sustainable travel choices, the Train stands out as a good way to reach San Diego. The journey takes about 2 days, 3 hours 53 minutes and with fares starting at just R 4 087, it presents an excellent value for a comfortable ride.
Where are the popular stops in Milwaukee and San Diego?
Stops in Milwaukee
- A
Milwaukee Airport
- B433 W St Paul Ave, Milwaukee, WI 53203, USA
- C
S Cesar Chavez
1016 S Cesar E Chavez Dr, Milwaukee, WI 53204, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
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Frequently asked questions about travelling from Milwaukee to San Diego, CA, US by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Milwaukee to San Diego?
The cheapest bus tickets from Milwaukee to San Diego start at R 2 320. The average price for this route is around R 4 022. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Milwaukee to San Diego?
The average bus journey time from Milwaukee to San Diego is 2d 16h, covering a distance of 2793 km. The fastest bus gets you there in 2d 10h and is operated by FlixBus.
Which bus companies service the Milwaukee to San Diego route?
What is the earliest and latest departure time for the bus from Milwaukee to San Diego?
The earliest bus departs from Milwaukee to San Diego at 06:30. And the latest bus departs at 19:55.
What are the CO₂ emissions for the bus trip from Milwaukee to San Diego?
A bus trip from Milwaukee to San Diego produces an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Milwaukee to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87518 reviews.
Which bus company has the best Wi-Fi from Milwaukee to San Diego?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Milwaukee to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Milwaukee to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Milwaukee to San Diego, CA, US was searched and found on 29 Jan 2026 with a price of R 2 679To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Milwaukee to San Diego, CA, US as early as possible.
You can expect to pay from R 2 679 to R 8 243 for a bus ticket from Milwaukee to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 835, which is on 2026-02-02.
What's the cheapest way to go from Milwaukee to San Diego, CA, US?
The Bus is the cheapest travel choice for this destination
