Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Durham Station | Depew Station | CheapestFastest | ||||
| Train | Durham Station | Depew Station | No tags | ||||
| Train | Durham Station | Exchange Street Station | No tags | ||||
| Train | Durham Station | Exchange Street Station | No tags |
Last refresh of the prices: Last Wednesday at 4:44 PM EDT.
Compare 2 ways to go from Durham to Buffalo
Among the sustainable travel choices, the Bus stands out as a good way to reach Buffalo. The journey takes about 21 hours 35 minutes, and with fares starting at just $146, it presents an excellent value for a comfortable ride.
Train companies
Based on 5784 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the Wi‑Fi. Amtrak ticket prices on this trip start at $251
Frequently asked questions about travelling from Durham, NC, US to Buffalo, NY by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Durham to Buffalo?
The cheapest train tickets from Durham to Buffalo start at $251. The average price for this train route is around $363. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from Durham to Buffalo?
The average train trip from Durham to Buffalo takes 1d 5h and covers 769 km. The quickest train gets you there in 1d 5h and is operated by Amtrak.
Which train operators serve the Durham to Buffalo route?
Several major train operators serve this route, with 2 trains available per day.
What are the earliest and latest departure times for the train from Durham to Buffalo?
The earliest train from Durham to Buffalo departs at 9:27am. The latest train departs at 10:12am.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Durham, NC, US to Buffalo, NY was searched and found on Apr 4, 2026 with a price of $504To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Durham, NC, US to Buffalo, NY, as early as possible.
You can expect to pay from $504 to $791 for a train ticket from Durham, NC, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $562 which is on 2026-04-06.
