Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Durham Station | Depew Station | No tags | ||||
| Train | Durham Station | Exchange Street Station | No tags | ||||
| Train | Durham Station | Exchange Street Station | No tags | ||||
| Train | Durham Station | Depew Station | No tags | ||||
| Train | Durham Station | Depew Station | No tags |
Compare 2 ways to go from Durham to Buffalo
Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 21 hours 35 minutes and with fares starting at just $141, it presents an excellent value for a comfortable ride.
Train Companies
Based on 5641 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $306
Frequently asked questions about traveling from Durham, NC, US to Buffalo, NY by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Durham to Buffalo?
The cheapest train tickets from Durham to Buffalo start from $306. The average price for this train route is around $335. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Durham to Buffalo?
The average train ride duration from Durham to Buffalo is 1d 5h, covering a distance of 475 miles (766 km). The quickest train can get you there in 1d 5h and is operated by Amtrak.
Which train operators service the Durham to Buffalo route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the train from Durham to Buffalo?
The earliest train departs from Durham to Buffalo at 9:27am. And the latest train departs at 9:27am.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Durham, NC, US to Buffalo, NY was searched and found on Dec 11, 2025 with a price of $214To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Durham, NC, US to Buffalo, NY, as early as possible.
