Next train departures

Next departures for Isernia to Rome on October 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train Wi‑Fi Toilet Power outlets	8:31am	Isernia	5h 51m	2:22pm	Termini	CheapestFastest

Next departures for Isernia to Rome on October 19
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train Wi‑Fi Toilet Power outlets	8:38am	Isernia	2h 9m	10:47am	Termini	CheapestFastest
Train Wi‑Fi Toilet Power outlets	3:03pm	Isernia	2h 24m	5:27pm	Termini	No tags
Train Wi‑Fi Toilet Power outlets	3:20pm	Isernia	5h	8:20pm	Termini	No tags
Train Wi‑Fi Toilet Power outlets	6:00pm	Isernia	2h 25m	8:25pm	Termini	No tags

Next departures for Isernia to Rome on October 22
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train Wi‑Fi Toilet Power outlets	8:38am	Isernia	2h 9m	10:47am	Termini	CheapestFastest
Train Wi‑Fi Toilet Power outlets	3:03pm	Isernia	2h 24m	5:27pm	Termini	No tags
Train Wi‑Fi Toilet Power outlets	3:20pm	Isernia	5h	8:20pm	Termini	No tags
Train Wi‑Fi Toilet Power outlets	4:45pm	Isernia	5h 3m	9:48pm	Termini	No tags
Train Wi‑Fi Toilet Power outlets	6:00pm	Isernia	2h 25m	8:25pm	Termini	No tags

Last refresh of the prices: Today at 4:24 PM CEST.

Compare 2 ways to go from Isernia to Rome

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Rome. The journey takes about 2 hours 25 minutes, and with fares starting at just $31, it presents an excellent value for a comfortable ride.

4train per day

2h 25mAverage Duration

148 kmDistance

4kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$20 - $131	Average Duration6h 35m	CO₂ emissions 4kg CO₂e
Train	Average Price$31 - $47	Average Duration2h 25m	CO₂ emissions 4kg CO₂e

Where are the popular train stations and stops in Isernia and Rome?

Isernia

A
Isernia
Piazza della Repubblica, 9, 86170 Isernia IS, Italy
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Rome

A
Termini
Piazza dei Cinquecento 1, 00185 Roma RM, Italy
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B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy
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C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy
Visit page
D
Roma S. Pietro
Roma S.Pietro, 00165 Roma RM, Italy
Visit page
E
Rome Ciampino Airport
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F
Roma Trastevere
Roma Trastevere Railway Station, 00152 Roma RM, Italy
Visit page

Train companies

Trenitalia

3.9/575 reviews

Staff4.5

Timeliness4.3

Cleanliness4.8

Wi‑Fi2.9

Based on 75 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the departure location but often complained with the Wi‑Fi. Trenitalia ticket prices on this trip start at $31

IT train companies:Trenitalia, Deutsche Bahn, FlixTrain, RegioJet, NS Nederlandse Spoorwegen, Deutsche Bahn Regio, Italo

Frequently asked questions about travelling from Isernia to Rome by train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the train ticket from Isernia to Rome?
The cheapest train tickets from Isernia to Rome start at $31. The average price for this train route is around $32. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from Isernia to Rome?
The average train trip from Isernia to Rome takes 2h 25m and covers 148 km. The quickest train gets you there in 2h 7m and is operated by Trenitalia.
Which train operators serve the Isernia to Rome route?
Several major train operators serve this route, with 4 trains available per day.
What are the earliest and latest departure times for the train from Isernia to Rome?
The earliest train from Isernia to Rome departs at 7:08am. The latest train departs at 8:35pm.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

10-15

$25

10-16

$25

Today

$25

10-18

$40

10-19

$25

10-20

$25

10-21

$25

10-22

$25

The cheapest trip from Isernia to Rome was searched and found on Oct 20, 2026 with a price of $25

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Isernia to Rome, as early as possible.

You can expect to pay from $25 to $40 for a train ticket from Isernia to Rome based on the last 2 days. You can expect to find the cheapest price for the trip at $25 which is on 2026-10-20.