Next available departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Isernia | Rome Tiburtina Bus Station | Cheapest | |||||
 | Isernia | Termini | Fastest | |||||
| Isernia | Termini | No tags | |||||
| Isernia | Rome Fiumicino Airport | No tags | |||||
| Isernia | Termini | No tags |
Last refresh of the prices: Last Monday at 17:30 CEST.
Compare 2 ways to travel from Isernia to Rome
Among the sustainable travel choices, the Train stands out as a good way to reach Rome. The journey takes about 2 hours 25 minutes and with fares starting at just ₪66, it presents an excellent value for a comfortable ride.
Where are the popular stops in Isernia and Rome?
Stops in Rome
- APiazza dei Cinquecento 1, 00185 Roma RM, Italy
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy - DRoma S.Pietro, 00165 Roma RM, Italy
- ERoma Trastevere Railway Station, 00152 Roma RM, Italy
- FCesano Di Roma, 00123 Roma RM, Italy
Compare companies
Frequently asked questions about travelling from Isernia to Rome by bus or train
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much does a ticket from Isernia to Rome cost?
The cheapest tickets from Isernia to Rome start from ₪41. The average price for this route is around ₪91. Busbud recommends that you book your tickets in advance for a better chance of getting the lowest possible price.
How long is the journey from Isernia to Rome?
The average trip duration from Isernia to Rome is 4h 40m, covering a distance of 95 miles. The quickest vehicle can get you there in 2h 7m and is operated by Trenitalia.
Which companies operate the Isernia to Rome route?
Several major companies operate on this route with 3 trips available per day, including services from FlixBus, Trenitalia.
What are the earliest and latest departure times from Isernia to Rome?
The earliest service departs from Isernia for Rome at 07:10. And the latest service departs at 20:35.
What are the CO₂ emissions for the journey from Isernia to Rome?
A journey from Isernia to Rome produces an estimated 3.8236 kg of CO₂, making it a highly eco-friendly way to travel and a mode of transport recommended by Busbud.
Which is the best company from Isernia to Rome?
According to Busbud customers, the highest-rated company on this route is Trenitalia, with an average rating of 3.9 out of 5 stars based on 58 reviews.
Which company has the best Wi-Fi from Isernia to Rome?
According to reviews on Busbud, the company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which company offers the most punctual service from Isernia to Rome?
According to Busbud traveller reviews, the most punctual company on this route is Trenitalia, with a punctuality rating of 4.6 out of 5 stars.
Which company has the cleanest vehicles from Isernia to Rome?
According to Busbud traveller reviews, the company with the cleanest vehicles on this route is Trenitalia, with a cleanliness rating of 4.7 out of 5 stars.
Find the cheapest prices for buses and trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Isernia to Rome was searched and found on 22 Apr 2026 with a price of ₪41To save money and ensure you get the best seat, it's a good idea to buy your bus and train tickets from Isernia to Rome, as early as possible.
You can expect to pay between ₪41 and ₪171 for a bus or train ticket from Isernia to Rome based on the past 2 days. You can expect to find the lowest price for the trip at ₪43 on 2026-04-27.
