Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Depew Station | Old Town San Diego | No tags | ||||
| Train | Depew Station | Santa Fe Depot | No tags | ||||
| Train | Depew Station | Santa Fe Depot | No tags | ||||
| Train | Depew Station | Old Town San Diego | No tags | ||||
| Train | Depew Station | Old Town San Diego | No tags |
Compare 2 ways to go from Buffalo to San Diego
Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 2 days, 15 hours 14 minutes, and with fares starting at just $498, it presents an excellent value for a comfortable ride.
Train companies
Based on 5625 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $498
Frequently asked questions about travelling from Buffalo, NY to San Diego, CA, US by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Buffalo to San Diego?
The cheapest train tickets from Buffalo to San Diego start at $498. The average price for this train route is around $499. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from Buffalo to San Diego?
The average train trip from Buffalo to San Diego takes 2d 15h and covers 3528 km. The quickest train gets you there in 2d 15h and is operated by Amtrak.
Which train operators serve the Buffalo to San Diego route?
Several major train operators serve this route, with 2 trains available per day.
What are the earliest and latest departure times for the train from Buffalo to San Diego?
The earliest train from Buffalo to San Diego departs at 12:39am. The latest train departs at 12:39am.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to San Diego, CA, US was searched and found on Dec 10, 2025 with a price of $479To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to San Diego, CA, US, as early as possible.
You can expect to pay from $479 to $2,788 for a train ticket from Buffalo, NY to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $479 which is on 2025-12-10.
What's the cheapest way to go from Buffalo, NY to San Diego, CA, US?
The train is the cheapest travel choice for this destinationThe best way to travel between Buffalo, NY and San Diego, CA, US is by train. By choosing the train, you'll get to save some money as you travel to your destination, as ticket prices cost $499 on average. If you're on a budget, you'll find cheap tickets from $498. If you're looking for the fastest way to get to San Diego, CA, US, choose the train, as it will take you from Buffalo, NY to San Diego, CA, US in about 2d 15h —that's the fastest way to get there!
