Bus Tickets from Buffalo, NY to San Diego, CA

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TomorrowMay 13
from US$303
WedMay 14
ThuMay 15
FriMay 16
SatMay 17
SunMay 18
MonMay 19
TueMay 20

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 13 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: May 17 at
    Destination city: San Diego
    Destination location: Balboa Park
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 13 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: May 16 at
    Destination city: San Diego
    Destination location: Downtown SD (Seaport)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 13 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: May 16 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 13 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: May 16 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 13 at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: May 16 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Today at 11:55 AM EDT.

Prices and availability are subject to change.

Accepted payments

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Compare 2 ways to go from Buffalo to San Diego

Average PriceUS$419 - US$554Average Duration3d 5h
88kg CO₂e5 out of 5 stars
Most eco-friendly
Average PriceUS$297 - US$559Average Duration2d 15h
321kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from Buffalo to San Diego

Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 2 days, 15 hours 14 minutes, and with fares starting at just US$297, it presents an excellent value for a comfortable ride.

2train per day
2d 15hAverage Duration
US$297Cheapest ticket
321kgCO₂ emissions

Bus Buffalo to San Diego: Trip Overview

Average Ticket PriceUS$498
Average Bus Trip Duration3d 5h
Number of daily buses19
Earliest bus departure7:55am
Distance3515 km
Latest bus departure11:20pm

Buffalo to San Diego Bus

Busbud helps you find a bus from Buffalo to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Buffalo to San Diego.

From cheap bus tickets to more luxurious buses travelling from Buffalo to San Diego, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Buffalo - San Diego

  1. How long is the trip from Buffalo to San Diego by bus?

    The trip from Buffalo to San Diego will take on average 3d 5h. For the shortest travel time, select the fastest bus available, which will take you to San Diego in about 2d 20h.

  2. What is the travel distance from Buffalo to San Diego?

    It's about 3518 km (2181 miles) from Buffalo to San Diego.

  3. What are the departure and arrival locations for buses traveling from Buffalo to San Diego?

    Buses departing from Buffalo Airport in Buffalo will take you to Mission Valley Sheraton in San Diego.

  4. How much does the bus ticket cost from Buffalo to San Diego?

    You can expect to pay around US$498 for the bus ride from Buffalo to San Diego.

  5. Is there an overnight bus from Buffalo to San Diego?

    Yes! If you're heading from Buffalo to San Diego, you'll find buses departing until 11:20pm and arriving the next day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-10
US$361
05-11
No data
Today
No data
05-13
US$326
05-14
No data
05-15
No data
05-16
No data
05-17
No data
busbud logoThe cheapest trip from Buffalo to San Diego was searched and found on May 13, 2025 with a price of US$326

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo to San Diego, as early as possible.

You can expect to pay from US$326 to US$361 for a bus ticket from Buffalo to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at US$326 which is on 2025-05-13.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Buffalo and San Diego!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Buffalo to San Diego.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Buffalo to San Diego that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Buffalo to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Buffalo by bus?

Bus from Buffalo to San Diego

You can also go to San Diego by train

Train from Buffalo to San Diego

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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