Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags | ||||
| Train | Depew Station | Gateway Station | No tags |
Compare 2 ways to go from Buffalo to St. Louis
Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 20 hours 28 minutes, and with fares starting at just $279, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Buffalo, NY and St. Louis?
Train companies
Based on 5607 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $279
Frequently asked questions about travelling from Buffalo, NY to St. Louis by train
How much does a cheap train ticket from Buffalo to St. Louis cost?
The average train ticket price from Buffalo to St. Louis is $337. The best way to find cheap train tickets from Buffalo to St. Louis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the trip from Buffalo to St. Louis?
A train trip between Buffalo and St. Louis is around 20h 28m, although the fastest train will take about 19h 28m. This is the time it takes to travel the 1065 km that separates the two cities.
How many daily trains are there between Buffalo and St. Louis?
The number of trains from Buffalo to St. Louis can differ depending on the day of the week. On average, there is 1. Some trains are direct while others have layovers. Simplify your train trip from Buffalo to St. Louis by comparing and selecting the train that fits your travel style and budget on Busbud.
Which train companies travel from Buffalo to St. Louis?
When taking the train from Buffalo to St. Louis, you can travel comfortably and safely with Amtrak.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Buffalo, NY to St. Louis was searched and found on Nov 23, 2025 with a price of $294To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to St. Louis, as early as possible.
You can expect to pay from $294 to $1,454 for a train ticket from Buffalo, NY to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $294 which is on 2025-11-26.
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