How much does a train ticket from Buffalo to St. Louis cost?

The average train ticket price from Buffalo to St. Louis is $234. The best way to find train tickets from Buffalo to St. Louis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the train trip from Buffalo to St. Louis?

A train trip between Buffalo and St. Louis is around 20h 28m, although the fastest train will take about 19h 28m. This is the time it takes to travel the 660 miles that separates the two cities.

How many daily trains are there between Buffalo and St. Louis?

The number of trains from Buffalo to St. Louis can differ depending on the day of the week. On average, there is 1. Some trains are direct while others have layovers. Simplify your train trip from Buffalo to St. Louis by comparing and selecting the train that fits you travel style and budget on Busbud.

Which train companies travel from Buffalo to St. Louis?

When taking the train from Buffalo to St. Louis, you can travel comfortably and safely with Amtrak.

What are the best sights and things to do in St. Louis?

Once in St. Louis, you can explore the city. The top sights and things to do are Anheuser-Busch Brewery, Forest Park, Old St. Louis County Courthouse, Saint Louis Zoo, Gateway Arch.

Train Buffalo to St. Louis from $101 | Refundable Tickets

Previously seen trips

Next departures for Buffalo to St. Louis on November 25
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Train	12:39am	Depew Station	19h 28m	7:07pm	Gateway Station	No tags
Train	12:39am	Depew Station	1d	12:09am	Gateway Station	No tags
Train	12:39am	Depew Station	1d	12:09am	Gateway Station	No tags
Train	12:39am	Depew Station	19h 28m	7:07pm	Gateway Station	No tags
Train	12:39am	Depew Station	19h 28m	7:07pm	Gateway Station	No tags

Compare 2 ways to go from Buffalo to St. Louis

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 20 hours 28 minutes and with fares starting at just $193, it presents an excellent value for a comfortable ride.

1train per day

20h 28mAverage Duration

668 milesDistance

98kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$111 - $350	Average Duration1d 10h	CO₂ emissions 27kg CO₂e
Train	Average Price$193 - $1,042	Average Duration20h 28m	CO₂ emissions 98kg CO₂e

Where are the popular train stations and stops in Buffalo, NY and St. Louis?

Buffalo, NY

A
Exchange Street Station
75 Exchange St, Buffalo, NY 14203, USA
Visit page

St. Louis

A
Gateway Station
430 S 15th St, St Louis, MO 63103
Visit page

Train Companies

Amtrak

4/55,607 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5607 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $193

Train and bus companies in US:Amtrak, Trenitalia, Renfe, VIA Rail Canada, Amtrak Acela, NS Nederlandse Spoorwegen, Iryo

Frequently asked questions about traveling from Buffalo, NY to St. Louis by train

How much does a train ticket from Buffalo to St. Louis cost?
How long is the train trip from Buffalo to St. Louis?
How many daily trains are there between Buffalo and St. Louis?
Which train companies travel from Buffalo to St. Louis?
What are the best sights and things to do in St. Louis?

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/23

$203

11/24

No data

Today

$203

11/26

$203

11/27

No data

11/28

No data

11/29

No data

11/30

$1,005

The cheapest trip from Buffalo, NY to St. Louis was searched and found on Nov 23, 2025 with a price of $203

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Buffalo, NY to St. Louis, as early as possible.

You can expect to pay from $203 to $1,005 for a train ticket from Buffalo, NY to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $203 which is on 2025-11-26.