Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Hlavní nádraží | Karlsruhe Hbf | Cheapest | |||||
Flixbus + Flixtrain | Prague (Na Knížecí) | Karlsruhe Hbf | Fastest | |||||
Flixbus + Flixtrain | Prague (Central Bus Station Florenc) | Karlsruhe Hbf | No tags | |||||
EuroCity Train + Deutsche Bahn ICE | Hlavní nádraží | Karlsruhe Hbf | No tags | |||||
| Hlavní nádraží | Karlsruhe Hbf | No tags |
Last refresh of the prices: Yesterday at 9:31 AM CET.
Compare 3 ways to go from Prague to Karlsruhe
Among the sustainable travel choices, the carpool stands out as a good way to reach Karlsruhe. The journey takes about 5 hours, and with fares starting at just $35, it presents an excellent value for a comfortable ride.
Train companies
Based on 1 reviews, the company was rated 5 stars on Busbud. Travellers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Deutsche Bahn EuroCity ticket prices on this trip start at $54
Where are the popular train stations and stops in Prague and Karlsruhe?
Frequently asked questions about travelling from Prague to Karlsruhe by train
How much does a cheap train ticket from Prague to Karlsruhe cost?
The average train ticket price from Prague to Karlsruhe is $180. The best way to find cheap train tickets from Prague to Karlsruhe is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the trip from Prague to Karlsruhe?
A train trip between Prague and Karlsruhe is around 9h 59m, although the fastest train will take about 9h 25m. This is the time it takes to travel the 453 km that separates the two cities.
How many daily trains are there between Prague and Karlsruhe?
The number of trains from Prague to Karlsruhe can differ depending on the day of the week. On average, there are 2. Some trains are direct while others include transferring trains. Simplify your train trip from Prague to Karlsruhe by comparing and selecting the train that fits your travel style and budget on Busbud.
Which train companies travel from Prague to Karlsruhe?
When taking the train from Prague to Karlsruhe, you can travel comfortably and safely with Deutsche Bahn EuroCity.
What are the departure and arrival stations for a train from Prague to Karlsruhe?
Trains travelling between Prague and Karlsruhe leave from Hlavní nádraží or Florenc and arrive at Karlsruhe Hbf, Südseite Hauptbahnhof.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Karlsruhe was searched and found on Nov 17, 2025 with a price of $52To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Karlsruhe, as early as possible.
You can expect to pay from $52 to $290 for a train ticket from Prague to Karlsruhe based on the last 2 days. You can expect to find the cheapest price for the trip at $52 which is on 2025-11-24.
