Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | PRG Airport | Südseite Hauptbahnhof | CheapestFastest | |||||
| Prague (Central Bus Station Florenc) | Südseite Hauptbahnhof | No tags | |||||
Flixbus + Flixtrain | Prague (Central Bus Station Florenc) | Karlsruhe Hbf | No tags | |||||
| Prague (Central Bus Station Florenc) | Südseite Hauptbahnhof | No tags | |||||
Flixbus + Flixtrain | Prague (Central Bus Station Florenc) | Karlsruhe Hbf | No tags |
Last refresh of the prices: Yesterday at 9:37 AM CET.
Compare 3 ways to go from Prague to Karlsruhe
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as a good way to reach Karlsruhe. The journey takes about 5 hours, and with fares starting at just $35, it presents an excellent value for a comfortable ride.
6carpool per day
5hAverage Duration
452 kmDistance
19kgCO₂ emissions
Compare bus companies
3.5 out of 5 stars3.5/511,380 reviews
3.5 out of 5 stars3.5/511,143 reviews
DE Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Where are the popular stops in Prague and Karlsruhe?
Stops in Prague
Stops in Karlsruhe
Frequently asked questions about travelling from Prague to Karlsruhe by bus
What is the distance between Prague and Karlsruhe?
The distance between Prague and Karlsruhe is around 453 km (281 miles).
What are the departure and arrival locations for buses traveling from Prague to Karlsruhe?
Buses traveling this route start their trip at Zličín, in Prague, and end it at Südseite Hauptbahnhof, in Karlsruhe.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-18
No data
11-19
$47
Today
$47
11-21
No data
11-22
No data
11-23
No data
11-24
No data
11-25
No data
The cheapest trip from Prague to Karlsruhe was searched and found on Nov 20, 2025 with a price of $47To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Karlsruhe, as early as possible.
