Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mainz | Prague (Main Railway Station) | Cheapest | ||||
| Bus | Mainz | Prague (Na Knížecí) | Fastest | ||||
| Bus | Mainz | Prague (Central Bus Station Florenc) | No tags | ||||
| Bus | Mainz | Prague (Main Station - parking) | No tags |
Last refresh of the prices: Today at 18:28 CET.
Compare 3 ways to travel from Mainz to Prague
Among the sustainable travel choices, the Carpool stands out as a good way to reach Prague. The journey takes about 5 hours 10 minutes and with fares starting at just £32, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mainz and Prague?
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz - Cflibco.com bus stop, Kaiser-Wilhelm-Ring, 55118 Mainz, Germany
Stops in Prague
- AKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- BAviatická, 161 08, Praha 6, Czechia
- CChlumecká, 198 00 Praha 20, Czech Republic
- DTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F300/8 Wilsonova, 110 00 Praha, Czechia
Compare bus companies
Based on 12303 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at £30
Frequently asked questions about travelling by bus from Mainz to Prague
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Mainz to Prague?
The cheapest coach tickets from Mainz to Prague start from £30. The average price for this route is around £42. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Mainz to Prague?
The average bus journey time from Mainz to Prague is 10h 25m, covering a distance of 273 miles. The fastest bus can take you there in 8h 5m and is operated by FlixBus.
Which bus companies service the Mainz to Prague route?
Several major bus companies operate on this route with 4 buses available per day.
What is the earliest and latest departure time for the bus from Mainz to Prague?
The earliest bus departs from Mainz to Prague at 05:15. And the latest bus departs at 23:30.
What are the CO₂ emissions for the bus trip from Mainz to Prague?
A bus journey from Mainz to Prague produces an estimated 11 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mainz to Prague was searched and found on 10 Mar 2026 with a price of £31To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mainz to Prague as early as possible.
You can expect to pay from £31 to £37 for a bus ticket from Mainz to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at £31, which is on 2026-03-10.
