Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mainz | Prague (Main Railway Station) | Cheapest | ||||
| Bus | Mainz | Prague (Na Knížecí) | Fastest | ||||
| Bus | Mainz | PRG Airport | No tags |
Last refresh of the prices: Yesterday at 4:24 AM CEST.
Compare 2 ways to go from Mainz to Prague
Among the sustainable travel choices, the Bus stands out as a good way to reach Prague. The journey takes about 8 hours 25 minutes and with fares starting at just HK$375, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mainz and Prague?
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz
Stops in Prague
- A
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - B
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - C
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - D
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Mainz to Prague by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mainz to Prague?
The cheapest bus tickets from Mainz to Prague start from HK$375. The average price for this route is around HK$451. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mainz to Prague?
The average bus trip duration from Mainz to Prague is 8h 25m, covering a distance of 272 miles (438 km). The quickest bus can get you there in 8h 5m and is operated by FlixBus.
Which bus companies service the Mainz to Prague route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Mainz to Prague?
The earliest bus departs from Mainz to Prague at 4:00pm. And the latest bus departs at 8:00pm.
What are the CO₂ emissions for the bus trip from Mainz to Prague?
A bus trip from Mainz to Prague generates an estimated 10.941975 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mainz to Prague was searched and found on Jun 8, 2026 with a price of HK$370To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mainz to Prague, as early as possible.
You can expect to pay from HK$370 to HK$584 for a bus ticket from Mainz to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at HK$370 which is on 2026-06-08.
What's the cheapest way to go from Mainz to Prague?
The Bus is the cheapest travel choice for this destination
