Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Hlavní nádraží | Brussels South/Midi Train Station | CheapestFastest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags |
Last refresh of the prices: Today at 04:33 CEST.
Compare 2 ways to travel from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 18 hours 25 minutes and with fares starting at just €39, it presents an excellent value for a comfortable ride.
15bus per day
18h 25mAverage duration
716 kmDistance
18kgCO₂ emissions
Where are the popular train stations and stops in Prague and Brussels?
Prague
- A300/8 Wilsonova, 110 00 Praha, Czechia
- B
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia - CKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- DAviatická, 161 08, Praha 6, Czechia
- E
Holešovice
Praha-Holešovice, Partyzánská 1546/26, 170 00 Praha 7-Holešovice, Czechia - FTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- B
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
07/04
€178
08/04
No data
Today
€158
10/04
No data
11/04
No data
12/04
€136
13/04
No data
14/04
€136
The cheapest trip from Prague to Brussels was searched and found on 12 Apr 2026 with a price of €136To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels as early as possible.
You can expect to pay from €136 to €626 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at €136, which is on 2026-04-12.