Next train departures

Next departures from Prague to Brussels on 31 March
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	18:00	Hlavní nádraží	16h 30m	10:30	Brussels South/Midi Train Station	CheapestFastest
	Train	18:00	Hlavní nádraží	16h 30m	10:30	Brussels South/Midi Train Station	No tags

Last refresh of the prices: Yesterday at 11:56 CEST.

Compare 2 ways to travel from Prague to Brussels

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 18 hours 25 minutes and with fares starting at just £34, it presents an excellent value for a comfortable ride.

14bus per day

18h 25mAverage duration

440 milesDistance

18kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average price£34 - £151	Average duration18h 25m	CO₂ emissions 18kg CO₂e
Train	Average price£52 - £212	Average duration15h 22m	CO₂ emissions 17kg CO₂e

Where are the popular train stations and stops in Prague and Brussels?

Prague

A
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
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B
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia
C
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
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D
PRG Airport
Aviatická, 161 08, Praha 6, Czechia
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E
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
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F
Holešovice
Praha-Holešovice, Partyzánská 1546/26, 170 00 Praha 7-Holešovice, Czechia

Brussels

A
Brussels South (Gare du Midi)
Rue de France 85, 1060 Saint-Gilles, Belgium
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B
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

28/03

No data

29/03

£165

Today

No data

31/03

£156

01/04

No data

02/04

£138

03/04

No data

04/04

No data

The cheapest trip from Prague to Brussels was searched and found on 2 Apr 2026 with a price of £138

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels as early as possible.

You can expect to pay from £138 to £549 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at £138, which is on 2026-04-02.