Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Hlavní nádraží | Brussels South/Midi Train Station | Cheapest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | Fastest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags |
Last refresh of the prices: Today at 04:46 CEST.
Compare 2 ways to travel from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the Bus stands out as a good way to reach Brussels. The journey takes about 18 hours and with fares starting at just CLP 41,434, it presents an excellent value for a comfortable ride.
26bus per day
18hAverage duration
443 milesDistance
18kgCO₂ emissions
Where are the popular train stations and stops in Prague and Brussels?
Prague
- A300/8 Wilsonova, 110 00 Praha, Czechia
- BPrague Main Railway Station, 120 00 Praha-Praha 2, Czechia
- CAviatická, 161 08, Praha 6, Czechia
- DKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- EChlumecká, 198 00 Praha 20, Czech Republic
- FPraha-Holešovice, Partyzánská 1546/26, 170 00 Praha 7-Holešovice, Czechia
Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- B
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
18/05
No data
19/05
CLP 132,608
Today
No data
21/05
CLP 287,092
22/05
No data
23/05
No data
24/05
CLP 397,507
25/05
No data
The cheapest trip from Prague to Brussels was searched and found on 19 May 2026 with a price of CLP 132,608To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels as early as possible.
You can expect to pay from CLP 132,608 to CLP 585,712 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at CLP 287,092, which is on 2026-05-21.
