Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Hlavní nádraží | Brussels South/Midi Train Station | Cheapest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | Fastest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags |
Last refresh of the prices: Yesterday at 9:59 PM CET.
Compare 2 ways to go from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as a good way to reach Brussels. The journey takes about 18 hours 40 minutes, and with fares starting at just $62, it presents an excellent value for a comfortable ride.
19bus per day
18h 40mAverage Duration
710 kmDistance
18kgCO₂ emissions
Where are the popular train stations and stops in Prague and Brussels?
Prague
- A300/8 Wilsonova, 110 00 Praha, Czechia
- BKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- CAviatická, 161 08, Praha 6, Czechia
- DChlumecká, 198 00 Praha 20, Czech Republic
- E
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia - FTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
Brussels
- ABoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- BRue de France 85, 1060 Saint-Gilles, Belgium
- C
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
12-12
No data
12-13
No data
Today
$221
12-15
No data
12-16
$221
12-17
No data
12-18
$255
12-19
No data
The cheapest trip from Prague to Brussels was searched and found on Dec 14, 2025 with a price of $221To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels, as early as possible.
You can expect to pay from $221 to $1,615 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $221 which is on 2025-12-16.