Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Hlavní nádraží | Brussels South/Midi Train Station | Cheapest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | Fastest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags |
Last refresh of the prices: Yesterday at 9:59 PM CET.
Compare 2 ways to go from Prague to Brussels
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Brussels. The journey takes about 18 hours 40 minutes and with fares starting at just $44, it presents an excellent value for a comfortable ride.
19bus per day
18h 40mAverage Duration
440 milesDistance
18kgCO₂ emissions
Where are the popular train stations and stops in Prague and Brussels?
Prague
- A300/8 Wilsonova, 110 00 Praha, Czechia
- BKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- CAviatická, 161 08, Praha 6, Czechia
- DChlumecká, 198 00 Praha 20, Czech Republic
- E
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia - FTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
Brussels
- ABoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- BRue de France 85, 1060 Saint-Gilles, Belgium
- C
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
12/12
No data
12/13
No data
Today
$157
12/15
No data
12/16
$157
12/17
No data
12/18
$181
12/19
No data
The cheapest trip from Prague to Brussels was searched and found on Dec 14, 2025 with a price of $157To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels, as early as possible.
You can expect to pay from $157 to $1,143 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at $157 which is on 2025-12-16.
