Next available departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Rome Tiburtina Bus Station | Isernia | Cheapest | |||||
 | Termini | Isernia | Fastest | |||||
| Rome Fiumicino Airport | Isernia | No tags | |||||
| Rome Fiumicino Airport | Isernia | No tags | |||||
| Aeroporto Ciampino Airport (CIA) | Isernia | No tags |
Last refresh of the prices: Today at 17:42 CEST.
Compare 2 ways to travel from Rome to Isernia
Among the sustainable travel choices, the Train stands out as a good way to reach Isernia. The journey takes about 2 hours 8 minutes and with fares starting at just THB 690, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Isernia?
Stops in Rome
- APiazza dei Cinquecento 1, 00185 Roma RM, Italy
- BLargo Guido Mazzoni, 3, 00162 Roma, Italy
- C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy - DRoma S.Pietro, 00165 Roma RM, Italy
- ERoma Trastevere Railway Station, 00152 Roma RM, Italy
- FCesano Di Roma, 00123 Roma RM, Italy
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Frequently asked questions about travelling from Rome to Isernia by bus or train
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is a ticket from Rome to Isernia?
The cheapest tickets from Rome to Isernia start at THB 435. The average price for this route is around THB 867. Busbud recommends booking your tickets in advance for a better chance of getting the lowest possible price.
How long is the journey from Rome to Isernia?
The average journey time from Rome to Isernia is 4h 36m, covering a distance of 151 km. The fastest vehicle can get you there in 2h 8m and is operated by Trenitalia.
Which companies operate the Rome to Isernia route?
Several major companies operate on this route with 2 departures available per day, including services from FlixBus, Trenitalia.
What are the earliest and latest departure times from Rome to Isernia?
The earliest trip from Rome to Isernia departs at 04:05. The latest trip departs at 23:55.
What are the CO₂ emissions for the journey from Rome to Isernia?
A journey from Rome to Isernia emits an estimated 3.7611125000000003 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Which is the best company from Rome to Isernia?
According to Busbud customers, the highest-rated company on this route is Trenitalia, with an average rating of 3.9 out of 5 stars based on 58 reviews.
Which company has the best Wi-Fi from Rome to Isernia?
According to reviews on Busbud, FlixBus has the best Wi-Fi rating with a score of 2.7.
Which company has the most punctual service from Rome to Isernia?
According to Busbud traveller reviews, the most timely company on this route is Trenitalia, with a punctuality rating of 4.6 out of 5 stars.
Which company has the cleanest vehicles from Rome to Isernia?
According to Busbud traveller reviews, the company with the cleanest vehicles on this route is Trenitalia, with a cleanliness rating of 4.7 out of 5 stars.
Find the cheapest prices for buses and trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Isernia was searched and found on 28 Apr 2026 with a price of THB 458To save money and make sure you get the best seat, it's a good idea to buy your bus and train tickets from Rome to Isernia, as early as possible.
You can expect to pay between THB 458 and THB 2,168 for a bus or train ticket from Rome to Isernia over the last 2 days. You can expect to find the lowest price for the trip at THB 458 on 2026-04-28.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
