What is the distance between Rome and Isernia?

The distance between Rome and Isernia is around 150 km (93 miles).

What are the departure and arrival locations for buses traveling from Rome to Isernia?

Buses traveling this route start their trip at Rome Tiburtina Bus Station, in Rome, and end it at Isernia, in Isernia.

Bus Rome to Isernia from $24 | Refundable Tickets

Next bus departures

Next departures for Rome to Isernia on November 19
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	5:10am	Rome Tiburtina Bus Station	6h 14m	11:24am	Isernia	CheapestFastest
Bus	4:05am	Rome Fiumicino Airport	7h 19m	11:24am	Isernia	No tags
Bus	4:40am	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24am	Isernia	No tags

Next departures for Rome to Isernia on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	2:45am	Rome Tiburtina Bus Station	8h 39m	11:24am	Isernia	CheapestFastest

Last refresh of the prices: Last Sunday at 4:09 PM CET.

Compare 3 ways to go from Rome to Isernia

We recommend carpooling

Among the sustainable travel choices, the carpool stands out as a good way to reach Isernia. The journey takes about 2 hours, and with fares starting at just $13, it presents an excellent value for a comfortable ride.

4carpool per day

2hAverage Duration

149 kmDistance

6kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$29 - $94	Average Duration6h 44m	CO₂ emissions 3kg CO₂e
Train	Average Price$30 - $31	Average Duration2h 48m	CO₂ emissions 4kg CO₂e
Carpool	Average Price$13 - $30	Average Duration2h	CO₂ emissions 6kg CO₂e

Compare bus companies

FlixBus

3.5/511,367 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Based on 11367 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. FlixBus ticket prices on this trip start at $29

IT Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Rede Expressos, Trenitalia

Where are the popular stops in Rome and Isernia?

Stops in Rome

A - Rome Tiburtina Bus Station

B - Rome Ciampino Airport

C - Rome Fiumicino Airport

D - Castro Pretorio

E - Roma

F - Anagnina

Stops in Isernia

A - Isernia

Frequently asked questions about travelling from Rome to Isernia by bus

What is the distance between Rome and Isernia?
The distance between Rome and Isernia is around 150 km (93 miles).
What are the departure and arrival locations for buses traveling from Rome to Isernia?
Buses traveling this route start their trip at Rome Tiburtina Bus Station, in Rome, and end it at Isernia, in Isernia.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-17

$34

11-18

$24

Today

$27

11-20

No data

11-21

$42

11-22

$36

11-23

$35

11-24

$32

The cheapest trip from Rome to Isernia was searched and found on Nov 18, 2025 with a price of $24

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Isernia, as early as possible.

You can expect to pay from $24 to $82 for a bus ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at $32 which is on 2025-11-24.