Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Isernia | CheapestFastest | ||||
| Bus | Rome Fiumicino Airport | Isernia | No tags | ||||
| Bus | Aeroporto Ciampino Airport (CIA) | Isernia | No tags |
Last refresh of the prices: Yesterday at 1:42 PM CET.
Compare 3 ways to travel from Rome to Isernia
Among the sustainable travel choices, the carpool stands out as a good way to reach Isernia. The journey takes about 2 hours and with fares starting at just R 155, it presents an excellent value for a comfortable ride.
Where are the popular stops in Rome and Isernia?
Stops in Rome
- ALargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Compare bus companies
Based on 11617 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at R 339
Frequently asked questions about travelling from Rome to Isernia by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Rome to Isernia?
The cheapest bus tickets from Rome to Isernia start at R 339. The average price for this route is around R 518. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Rome to Isernia?
The average bus journey time from Rome to Isernia is 6h 44m, covering a distance of 167 km. The fastest bus gets you there in 2h 10m and is operated by FlixBus.
Which bus companies service the Rome to Isernia route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Rome to Isernia?
The earliest bus departs from Rome to Isernia at 02:45. And the latest bus departs at 14:50.
What are the CO₂ emissions for the bus trip from Rome to Isernia?
A bus trip from Rome to Isernia produces an estimated 4 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Isernia was searched and found on 14 Dec 2025 with a price of R 310To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Isernia as early as possible.
You can expect to pay from R 310 to R 1 017 for a bus ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at R 333, which is on 2025-12-16.
