Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Isernia | CheapestFastest |
Last refresh of the prices: Last Sunday at 16:33 CET.
Compare 3 ways to travel from Rome to Isernia
Among the sustainable travel choices, the carpool stands out as a good way to reach Isernia. The journey takes about 2 hours and with fares starting at just £7, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 11378 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £16
Where are the popular stops in Rome and Isernia?
Frequently asked questions about travelling by bus from Rome to Isernia
What's the distance between Rome and Isernia by coach?
The distance between Rome and Isernia by coach is approximately 93 miles (150 km).
What is the best way to go from Rome to Isernia without a car?
You can travel to Isernia from Rome by coach, which provides a smooth ride and an affordable and convenient trip. Depending on your preferences, carpooling can also be considered as an option.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Isernia was searched and found on 18 Nov 2025 with a price of £13To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Isernia as early as possible.
You can expect to pay from £13 to £45 for a bus ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at £18, which is on 2025-11-24.
