Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Chicago (Bus Station) | 314 Jay St., La Crosse | CheapestFastest | ||||
| Bus | Chicago (Bus Station) | La Crosse (U of WI) | No tags |
Last refresh of the prices: Yesterday at 3:38 PM CST.
Compare 2 ways to travel from Chicago to La Crosse
Among the sustainable travel choices, the Train stands out as a good way to reach La Crosse. The journey takes about 5 hours 1 minute and with fares starting at just R 563, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 764 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Jefferson Lines ticket prices on this trip start at R 3 105
Frequently asked questions about travelling from Chicago to La Crosse, WI by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Chicago to La Crosse?
The cheapest bus tickets from Chicago to La Crosse start at R 3 105. The average price for this route is around R 3 417. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Chicago to La Crosse?
The average bus journey time from Chicago to La Crosse is 17h 10m, covering a distance of 364 km. The fastest bus gets you there in 17h 10m and is operated by Jefferson Lines.
Which bus companies service the Chicago to La Crosse route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Chicago to La Crosse?
The earliest bus departs from Chicago to La Crosse at 21:15. And the latest bus departs at 21:15.
What are the CO₂ emissions for the bus trip from Chicago to La Crosse?
A bus trip from Chicago to La Crosse produces an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to La Crosse, WI was searched and found on 11 Jan 2026 with a price of R 3 026To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to La Crosse, WI as early as possible.
