Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Chicago (Bus Station) | 314 Jay St., La Crosse | Cheapest | ||||
| Bus | Chicago (Bus Station) | 314 Jay St., La Crosse | Fastest | ||||
Jefferson Lines + Jefferson Lines | Bus | Chicago (Bus Station) | 314 Jay St., La Crosse | No tags | ||||
| Bus | Chicago (Bus Station) | La Crosse (U of WI) | No tags | ||||
| Bus | Chicago (Bus Station) | La Crosse (U of WI) | No tags |
Last refresh of the prices: Last Sunday at 10:40 PM CST.
Compare 2 ways to go from Chicago to La Crosse
Among the sustainable travel choices, the Train stands out as a good way to reach La Crosse. The journey takes about 5 hours 1 minute, and with fares starting at just $47, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 766 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Jefferson Lines ticket prices on this trip start at $257
Frequently asked questions about travelling from Chicago to La Crosse, WI by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to La Crosse?
The cheapest bus tickets from Chicago to La Crosse start from $257. The average price for this route is around $257. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to La Crosse?
The average bus travel time from Chicago to La Crosse is 17h 35m, covering a distance of 365 km. The quickest bus can get you there in 17h 10m and is operated by Jefferson Lines.
Which bus companies service the Chicago to La Crosse route?
Several major bus companies operate on this route with 2 buses available per day.
What are the earliest and latest departure times for the bus from Chicago to La Crosse?
The earliest bus departs from Chicago to La Crosse at 9:15pm. And the latest bus departs at 9:15pm.
What are the CO₂ emissions for the bus trip from Chicago to La Crosse?
A bus trip from Chicago to La Crosse generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to La Crosse, WI was searched and found on Feb 15, 2026 with a price of $251To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to La Crosse, WI, as early as possible.
You can expect to pay from $251 to $251 for a bus ticket from Chicago to La Crosse, WI based on the last 2 days. You can expect to find the cheapest price for the trip at $251 which is on 2026-02-18.
