Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Columbus (E Mound St) | Knoxville Bus Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 100 E Rich St | Knoxville Bus Station | Fastest | ||||
| Bus | Columbus (E Mound St) | Knoxville Bus Station | No tags |
Last refresh of the prices: Yesterday at 9:22 PM EST.
Get from Columbus to Knoxville
The journey takes about 13 hours 25 minutes, and with fares starting at just R 1 235, it presents an excellent value for a comfortable ride.
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Where are the popular stops in Columbus and Knoxville?
Frequently asked questions about travelling from Columbus, OH to Knoxville, TN by bus
How much does a bus ticket from Columbus to Knoxville cost?
The bus ticket price from Columbus to Knoxville starts at R 1 235. The best way to find cheap bus tickets from Columbus to Knoxville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Columbus to Knoxville?
The average travel time between Columbus and Knoxville is around 13h 25m, although the fastest bus will take about 9h 10m. This is the time it takes to travel the 453 km that separates the two cities.
How many daily bus connections are there between Columbus and Knoxville?
The number of buses from Columbus to Knoxville can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Columbus to Knoxville by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Columbus to Knoxville?
When taking the bus from Columbus to Knoxville, you can travel comfortably and safely with Greyhound, FlixBus.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Columbus, OH to Knoxville, TN was searched and found on 20 Nov 2025 with a price of R 1 337To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Knoxville, TN as early as possible.
You can expect to pay from R 1 337 to R 1 953 for a bus ticket from Columbus, OH to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 337, which is on 2025-11-20.
