Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Where are the popular stops in Columbus and Knoxville?
Stops in Columbus
A - Columbus Bus Station
25 E Rich St, Columbus, OH 43205, USA
Stops in Knoxville
A - 100 Kirkwood St
Knoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA100 Kirkwood St
Frequently asked questions about traveling from Columbus, OH to Knoxville, TN by bus
What is the travel distance from Columbus to Knoxville?
The distance separating Columbus and Knoxville is 281 miles (453 km).
What are the departure and arrival stations when taking the bus from Columbus to Knoxville?
Buses going from Columbus to Knoxville start their journey at Columbus Bus Station and reach their destination at 100 Kirkwood St.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/16
$100
11/17
$103
Today
No data
11/19
$97
11/20
$76
11/21
$108
11/22
No data
11/23
No data
The cheapest trip from Columbus, OH to Knoxville, TN was searched and found on Nov 20, 2025 with a price of $76
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Knoxville, TN, as early as possible.
You can expect to pay from $76 to $111 for a bus ticket from Columbus, OH to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $76 which is on 2025-11-20.
The cheapest trip from Columbus, OH to Knoxville, TN was searched and found on Nov 20, 2025 with a price of $76
