Find coaches from Des Moines to Sioux Falls

Previously seen journeys

Next departures from Des Moines to Sioux Falls on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Jefferson Lines
Des Moines
Sioux FallsNo tags
Jefferson Lines
Des Moines
Sioux FallsNo tags
Jefferson Lines
Des Moines
Sioux FallsNo tags
Jefferson Lines
Des Moines
Sioux FallsNo tags
Jefferson Lines
Des Moines
Sioux FallsNo tags

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Get from Des Moines to Sioux Falls

busbud logoThis route is served by bus only

The journey takes about 14 hours 45 minutes, and with fares starting at just US$125, it presents an excellent value for a comfortable ride.

4bus per day
14h 45mAverage duration
339 kmDistance
8kgCO₂ emissions

Bus Des Moines to Sioux Falls: Trip Overview

Average ticket priceUS$143
Average bus trip duration14h 45m
Number of daily buses4
Earliest bus departure03:55
Distance339 km
Latest bus departure18:15

Des Moines to Sioux Falls Bus

With Busbud, comparing and booking tickets for a bus from Des Moines to Sioux Falls is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Des Moines to Sioux Falls will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Sioux Falls from Des Moines, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Des Moines - Sioux Falls

  1. How much does a bus ticket from Des Moines to Sioux Falls cost?

    The bus ticket price from Des Moines to Sioux Falls starts at US$125. The best way to find cheap bus tickets from Des Moines to Sioux Falls is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Des Moines to Sioux Falls?

    The average travel time between Des Moines and Sioux Falls is around 14h 45m, although the fastest bus will take about 5h 50m. This is the time it takes to travel the 330 km that separates the two cities.

  3. How many daily bus connections are there between Des Moines and Sioux Falls?

    The number of buses from Des Moines to Sioux Falls can differ depending on the day of the week. On average, there are 4 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Des Moines to Sioux Falls by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Des Moines to Sioux Falls?

    When taking the bus from Des Moines to Sioux Falls, you can travel comfortably and safely with Jefferson Lines.

  5. What are the departure and arrival stations when taking the bus from Des Moines to Sioux Falls?

    Buses travelling between Des Moines and Sioux Falls leave from Jefferson/Trailways Depot or 1514 East Grand Ave and arrive at Jefferson Lines Station I-29 & Maple St.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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05/11
US$168
busbud logoThe cheapest trip from Des Moines to Sioux Falls was searched and found on 05 Nov 2025 with a price of US$168

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Sioux Falls as early as possible.

You can expect to pay from US$168 to US$168 for a bus ticket from Des Moines to Sioux Falls based on the last 2 days. You can expect to find the cheapest price for the trip at US$168, which is on 2025-11-05.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Des Moines to Sioux Falls.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Des Moines to Sioux Falls, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Des Moines to Sioux Falls.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Des Moines to Sioux Falls.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Des Moines by bus?

Bus from Sioux Falls to Des Moines

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