Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | 1116 Woodruff Rd | Buffalo (BUF) Airport | Cheapest | ||||
 | Bus | 1116 Woodruff Rd | Buffalo (BUF) Airport | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | 1116 Woodruff Rd | Niagara Frontier Transportation Authority | No tags | ||||
 | Bus | 1116 Woodruff Rd | Niagara Frontier Transportation Authority | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 1116 Woodruff Rd | Niagara Frontier Transportation Authority | No tags |
Last refresh of the prices: Last Thursday at 4:06 PM EST.
Get from Greenville to Buffalo
The journey takes about 1 day, 1 hour 30 minutes, and with fares starting at just R 1 758, it presents an excellent value for a comfortable ride.
Where are the popular stops in Greenville and Buffalo?
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Stops in Buffalo
- A
Buffalo Airport
- B185 Ellicott St, Buffalo, NY 14203, USA
- C75 Exchange St, Buffalo, NY 14203, USA
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Frequently asked questions about travelling from Greenville, SC to Buffalo, NY by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Greenville to Buffalo?
The cheapest bus tickets from Greenville to Buffalo start at R 1 758. The average price for this route is around R 2 822. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Greenville to Buffalo?
The average bus journey time from Greenville to Buffalo is 1d 1h, covering a distance of 944 km. The fastest bus gets you there in 1d and is operated by FlixBus.
Which bus companies service the Greenville to Buffalo route?
What is the earliest and latest departure time for the bus from Greenville to Buffalo?
The earliest bus departs from Greenville to Buffalo at 07:25. And the latest bus departs at 22:00.
What are the CO₂ emissions for the bus trip from Greenville to Buffalo?
A bus trip from Greenville to Buffalo produces an estimated 24 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Greenville to Buffalo?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11504 reviews.
Which bus company has the best Wi-Fi from Greenville to Buffalo?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Greenville to Buffalo?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Buffalo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Buffalo, NY was searched and found on 15 Dec 2025 with a price of R 2 110To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Buffalo, NY as early as possible.
You can expect to pay from R 2 110 to R 3 251 for a bus ticket from Greenville, SC to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 810, which is on 2025-12-16.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
