Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Knoxville Bus Station | Chicago 95Th & Dan Ryan | Cheapest | |||||
 | Knoxville Bus Station | 537-517 W. Jackson Blvd | Fastest | |||||
| Knoxville Bus Station | Downtown Greyhound Station | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Knoxville Bus Station | Downtown Greyhound Station | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Knoxville Bus Station | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Last Monday at 9:34 PM EDT.
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Get from Knoxville to Chicago
This route is served by bus onlyThe journey takes about 16 hours 40 minutes, and with fares starting at just US$65, it presents an excellent value for a comfortable ride.
Bus Knoxville, TN to Chicago: Trip Overview
Compare bus companies
Based on 87342 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at US$116
Greyhound Knoxville Chicago recent customer reviews
the bus was supposed to leave Knoxville at 7:10 pm but left at 10:00 pm. We didn't know when the bus would leave, we got a lot of stress. In addition, there is no bus station building in Knoxville and we were on the street all this time. Since the bus left late, I missed my bus from Nashville to Chicago. and instead of arriving in Chicago at 8:35 am, I arrived at 1:00 pm. I wrote to the support service, I wanted to return the ticket due to the bus being late and fly by plane, but they answered me with automatic messages. the bus was supposed to leave Knoxville at 7:10 pm but left at 10:00 pm. We didn't know when the bus would leave, we got a lot of stress. In addition, there is no bus station building in Knoxville and we were on the street all this time. Since the bus left late, I missed my bus from Nashville to Chicago. and instead of arriving in Chicago at 8:35 am, I arrived at 1:00 pm. and I also didn’t like that they woke me up and kicked me off the bus at every stop
Artur T.
We were waylaid for an incredible 7 hours between Knoxville and Nashville because of an extremely suspect technical issue regarding the brightness of headlights. During this time a customer, understandably dissatisfied with the ride and the information given to them, expressed this to the driver whereupon the driver called the police on the passenger who was escorted off the bus by cops. Following our arrival into Knoxville we were again delayed when, due to understaffing, we were unable to get our redirected tickets in time. The actual ticketing staff at the Nashville terminal is the only reason the employees get 2 stars. He deserves a raise and probably a better job. Finally, after everything was sorted and we made our way into Chicago, our luggage went untransfered in Indianapolis and we had to return to get it the next day. This was a nightmarish ordeal and I will, from here on out, be spending my money on alternative methods of transportation.
Willem D.
It took us to get to home 24hrs instead 12 hrs with additional cost of $230 due to delay and no bus available at connections.
Nareshkumar P.
Knoxville to Chicago Bus
With Busbud, comparing and booking tickets for a bus from Knoxville to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
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Where are the popular stops in Knoxville and Chicago?
Frequently asked questions on the trip Knoxville, TN - Chicago
How much does a bus ticket from Knoxville to Chicago cost?
The bus ticket price from Knoxville to Chicago starts at US$65. The best way to find cheap bus tickets from Knoxville to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Knoxville to Chicago?
The average travel time between Knoxville and Chicago is around 16h 40m, although the fastest bus will take about 13h 40m. This is the time it takes to travel the 731 km that separates the two cities.
How many daily bus connections are there between Knoxville and Chicago?
The number of buses from Knoxville to Chicago can differ depending on the day of the week. On average, there are 6 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Knoxville to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Knoxville to Chicago?
When taking the bus from Knoxville to Chicago, you can travel comfortably and safely with Greyhound.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Chicago was searched and found on 31 Oct 2025 with a price of US$123To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Chicago as early as possible.
You can expect to pay from US$123 to US$230 for a bus ticket from Knoxville, TN to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$123, which is on 2025-10-31.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Knoxville to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Knoxville to Chicago, get comfy and count the stars.
Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Knoxville to Chicago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.
Tune out to the fine sounds of your best music playlist on your bus trip from Knoxville to Chicago while indulging in miles on end of beautiful scenic views.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
Top travelled bus routes
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Coach Knoxville - Marathon
- Bus Knoxville - Lexington
- Bus from Knoxville to Orlando
- Coach Knoxville - Chicago
- Bus Knoxville - Greenville
- Bus from Knoxville to Longview
- Coach Knoxville - Athens
- Bus Knoxville - Van Buren
- Bus from Knoxville to Lawrence
- Coach Knoxville - Warner Robins
- Bus Knoxville - Ithaca
- Bus from Knoxville to Akron
- Coach Knoxville - Savannah
- Bus Knoxville - Joplin
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Coach Memphis - Knoxville
- Bus Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Coach Tampa - Knoxville
- Bus Detroit - Knoxville
- Bus from Rockford to Knoxville
- Coach Easton - Knoxville
- Bus Deming - Knoxville
- Bus from Spartanburg to Knoxville
- Coach Portsmouth - Knoxville
- Bus Jacksonville - Knoxville
- Bus from Lansing to Knoxville
- Coach Naples - Knoxville
- Bus Athens - Knoxville
Popular Buses Connecting Chicago
Buses Leaving from Chicago
- Bus from Chicago to Columbia
- Coach Chicago - Toronto
- Bus Chicago - Seattle
- Bus from Chicago to Orlando
- Coach Chicago - Mexico City
- Bus Chicago - Washington
- Bus from Chicago to Iowa City
- Coach Chicago - Wildwood
- Bus Chicago - Centralia
- Bus from Chicago to Lewiston
- Coach Chicago - Mount Pleasant
- Bus Chicago - Kingman
- Bus from Chicago to Elkton
- Coach Chicago - Opelousas
- Bus Chicago - Brownsville
Buses Going to Chicago
- Bus from Boston to Chicago
- Coach Toronto - Chicago
- Bus Atlanta - Chicago
- Bus from Indianapolis to Chicago
- Coach Bridgeport - Chicago
- Bus Hamilton - Chicago
- Bus from Springfield to Chicago
- Coach Nashville - Chicago
- Bus Long Beach - Chicago
- Bus from Hickory to Chicago
- Coach Amsterdam - Chicago
- Bus Albion - Chicago
- Bus from Kerrville to Chicago
- Coach Boca Raton - Chicago
- Bus Lexington - Chicago
Popular routes in this country
- Bus from Buffalo to Niagara Falls
- Coach Houston - Brownsville
- Bus New York City - Fleischmanns
- Bus from Miami to Orlando
- Coach Newark - Norfolk
- Bus Milwaukee - Appleton
- Bus from New York City to Pittsburgh
- Coach Harrisonburg - Blacksburg
- Bus Alexandria - Charlottesville
- Bus from Norfolk to Newark
- Coach Hartford - New York City
- Bus Rancho Cucamonga - Los Angeles
- Bus from Brownsville to Houston