Find coaches from Mesa to San Diego, CA, US

Previously seen journeys

Next departures from Mesa to San Diego on 30 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Mesa Bus Stop
5716 Hardy AveNo tags
FlixBus + Greyhound
Mesa Bus Stop
UCSD Health La Jolla StationNo tags
Greyhound + FlixBus
Mesa Bus Stop
Downtown SD (Seaport)No tags
Greyhound + FlixBus
Mesa Bus Stop
San Diego (Old Town-FlixBus)No tags
Greyhound + FlixBus
Mesa Bus Stop
Balboa ParkNo tags

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Get from Mesa to San Diego

busbud logoThis route is served by bus only

The journey takes about 15 hours 35 minutes, and with fares starting at just US$44, it presents an excellent value for a comfortable ride.

3bus per day
15h 35mAverage duration
505 kmDistance
13kgCO₂ emissions

Bus Mesa to San Diego, CA, US: Trip Overview

Average ticket priceUS$126
Average bus trip duration15h 35m
Number of daily buses3
Earliest bus departure20:10
Distance504 km
Latest bus departure21:10

Mesa to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Mesa to San Diego.

We make it our job to connect you with the most dependable bus companies that cover bus service from Mesa to San Diego.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from Mesa, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Mesa - San Diego, CA, US

  1. How much does a bus ticket from Mesa to San Diego cost?

    The bus ticket price from Mesa to San Diego starts at US$44. The best way to find cheap bus tickets from Mesa to San Diego is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Mesa to San Diego?

    The average travel time between Mesa and San Diego is around 15h 35m, although the fastest bus will take about 13h 30m. This is the time it takes to travel the 502 km that separates the two cities.

  3. How many daily bus connections are there between Mesa and San Diego?

    The number of buses from Mesa to San Diego can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Mesa to San Diego by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Mesa to San Diego?

    When taking the bus from Mesa to San Diego, you can travel comfortably and safely with Greyhound.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$81
29/10
US$105
Today
No data
31/10
No data
01/11
No data
02/11
No data
03/11
No data
04/11
No data
busbud logoThe cheapest trip from Mesa to San Diego, CA, US was searched and found on 28 Oct 2025 with a price of US$81

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to San Diego, CA, US as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Mesa to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Mesa to San Diego.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Mesa to San Diego.

Tune out to the fine sounds of your best music playlist on your bus trip from Mesa to San Diego while indulging in miles on end of beautiful scenic views.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to Mesa by bus?

Bus from San Diego, CA, US to Mesa

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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