Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mesa Bus Stop | Greyhound Bus Stop | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | San Diego (Old Town-FlixBus) | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | UCSD Health La Jolla Station | No tags |
Last refresh of the prices: Last Saturday at 12:40 AM MST.
Get from Mesa to San Diego
The journey takes about 19 hours 45 minutes and with fares starting at just PEN 213, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and San Diego?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Mesa to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mesa to San Diego?
The cheapest bus tickets from Mesa to San Diego start from PEN 213. The average price for this route is around PEN 353. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mesa to San Diego?
The average bus trip duration from Mesa to San Diego is 19h 45m, covering a distance of 313 miles (505 km). The quickest bus can get you there in 15h 35m and is operated by Greyhound.
Which bus companies service the Mesa to San Diego route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from Mesa to San Diego?
The earliest bus departs from Mesa to San Diego at 6:15pm. And the latest bus departs at 8:10pm.
What are the CO₂ emissions for the bus trip from Mesa to San Diego?
A bus trip from Mesa to San Diego generates an estimated 12.6074 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to San Diego, CA, US was searched and found on May 4, 2026 with a price of PEN 187To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to San Diego, CA, US, as early as possible.
You can expect to pay from PEN 187 to PEN 302 for a bus ticket from Mesa to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at PEN 187 which is on 2026-05-04.
