Bus Tickets from Mesa to San Diego, CA, US

Next departures

Next departures for Mesa to San Diego on October 6
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Mesa Bus Stop
Greyhound Bus StopCheapestFastest
Greyhound Lines, Inc. + FlixBus
Mesa Bus Stop
San Diego (Old Town-FlixBus)No tags

Last refresh of the prices: Last Wednesday at 12:26 PM MST.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Mesa to San Diego, CA, US: Trip Overview

Average ticket price$63
Average bus trip duration15h 35m
Number of daily buses4
Earliest bus departure8:10pm
Distance313 miles (504 km)

Mesa to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Mesa to San Diego.

We make it our job to connect you with the most dependable bus companies that cover bus service from Mesa to San Diego.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from Mesa, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Mesa - San Diego, CA, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/03
No data
10/04
$132
Today
No data
10/06
$63
10/07
No data
10/08
No data
10/09
No data
10/10
No data
busbud logoThe cheapest trip from Mesa to San Diego, CA, US was searched and found on Oct 6, 2025 with a price of $63

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to San Diego, CA, US, as early as possible.

You can expect to pay from $63 to $132 for a bus ticket from Mesa to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $63 which is on 2025-10-06.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Mesa to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Mesa to San Diego.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Mesa to San Diego.

Tune out to the fine sounds of your best music playlist on your bus trip from Mesa to San Diego while indulging in miles on end of beautiful scenic views.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to Mesa by bus?

Bus from San Diego, CA, US to Mesa

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Mesa

Buses Leaving from Mesa

Buses Going to Mesa

Popular Buses Connecting San Diego

Buses Leaving from San Diego

Buses Going to San Diego