Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Panama City Beach Station | Gainesville Bus Stop | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Panama City Beach Station | Rosa Parks Station | Fastest |
Last refresh of the prices: Last Sunday at 9:21 AM CST.
Get from Panama City to Gainesville
The journey takes about 5 hours 55 minutes, and with fares starting at just R 844, it presents an excellent value for a comfortable ride.
Where are the popular stops in Panama City and Gainesville?
Stops in Gainesville
- A700 SE 3rd St, Gainesville, FL 32601
- B3509 SW Williston Rd, Gainesville, FL 32608, USA
- C101 NE 23rd Ave, Gainesville, FL 32609
Compare bus companies
Based on 87499 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 844
Frequently asked questions about travelling from Panama City, US to Gainesville, FL by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Panama City to Gainesville?
The cheapest bus tickets from Panama City to Gainesville start at R 844. The average price for this route is around R 1 751. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Panama City to Gainesville?
The average bus journey time from Panama City to Gainesville is 5h 55m, covering a distance of 334 km. The fastest bus gets you there in 10h 40m and is operated by Greyhound.
Which bus companies service the Panama City to Gainesville route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Panama City to Gainesville?
The earliest bus departs from Panama City to Gainesville at 07:30. And the latest bus departs at 12:50.
What are the CO₂ emissions for the bus trip from Panama City to Gainesville?
A bus trip from Panama City to Gainesville produces an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Panama City, US to Gainesville, FL was searched and found on 12 Jan 2026 with a price of R 1 160To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Gainesville, FL as early as possible.
You can expect to pay from R 1 160 to R 1 816 for a bus ticket from Panama City, US to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 379, which is on 2026-01-16.
