Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Florenc | Lyon - Gerland Bus Station | CheapestFastest |
Last refresh of the prices: 06/11/2026 CEST.
Get from Prague to Lyon
The journey takes about 19 hours 5 minutes, and with fares starting at just R 1 021, it presents an excellent value for a comfortable ride.
Where are the popular stops in Prague and Lyon?
Stops in Prague
- A
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - B
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - C
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - D
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - E
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Lyon
- B
Perrache
Rue de Esplanade, 69002 Lyon, France - C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - F
Les Charrières
Les Charrières, 69570 Dardilly, France
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Frequently asked questions about travelling from Prague to Lyon by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Prague to Lyon?
The cheapest bus tickets from Prague to Lyon start at R 1 021. The average price for this route is around R 1 539. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Prague to Lyon?
The average bus journey time from Prague to Lyon is 19h 5m, covering a distance of 857 km. The fastest bus gets you there in 14h 50m and is operated by FlixBus.
Which bus companies service the Prague to Lyon route?
Several major bus companies operate on this route with 19 buses available per day, including services from FlixBus, RegioJet, BlaBlaCar Bus.
What is the earliest and latest departure time for the bus from Prague to Lyon?
The earliest bus departs from Prague to Lyon at 02:30. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Prague to Lyon?
A bus trip from Prague to Lyon produces an estimated 21.419825 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Prague to Lyon?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1079 reviews.
Which bus company has the best Wi-Fi from Prague to Lyon?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.9.
Which bus company offers the most punctual service from Prague to Lyon?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Prague to Lyon?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Lyon was searched and found on 18 Jun 2026 with a price of R 991To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Lyon as early as possible.
You can expect to pay from R 991 to R 3 396 for a bus ticket from Prague to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 038, which is on 2026-06-19.
