Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | PRG Airport | Gare routière de Gerland | Cheapest | ||||
| Bus | Prague (Na Knížecí) | Gare routière de Gerland | Fastest | ||||
| Bus | Prague (Central Bus Station Florenc) | Gare routière de Gerland | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Gare routière de Gerland | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Gare routière de Gerland | No tags | ||||
| Bus | Prague (Central Bus Station Florenc) | Gare routière de Gerland | No tags | ||||
| Bus | Prague (Main Station - parking) | Gare routière de Gerland | No tags | ||||
| Bus | Prague (Main Station - parking) | Gare routière de Gerland | No tags |
Last refresh of the prices: Yesterday at 4:57 AM CEST.
Get from Prague to Lyon
The journey takes about 19 hours 10 minutes and with fares starting at just MAD 534, it presents an excellent value for a comfortable ride.
Bus stations and stops in Prague and Lyon
Stops in Prague
- A
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - B
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - C
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - D
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - E
Tomíčkova
Tomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia - F
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia
Stops in Lyon
- B
Perrache
Rue de Esplanade, 69002 Lyon, France - C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - F
Les Charrières
Les Charrières, 69570 Dardilly, France
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Frequently asked questions about traveling from Prague to Lyon by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Prague to Lyon?
The cheapest bus tickets from Prague to Lyon start from MAD 534. The average price for this route is around MAD 1,013. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Prague to Lyon?
The average bus trip duration from Prague to Lyon is 19h 10m, covering a distance of 531 miles (857 km). The quickest bus can get you there in 14h 50m and is operated by FlixBus.
Which bus companies service the Prague to Lyon route?
Several major bus companies operate on this route with 23 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What is the earliest and latest departure time for the bus from Prague to Lyon?
The earliest bus departs from Prague to Lyon at 2:30am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Prague to Lyon?
A bus trip from Prague to Lyon generates an estimated 21.402600000000003 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Prague to Lyon?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1103 reviews.
Which bus company has the best Wi-Fi from Prague to Lyon?
Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company has the most timely service from Prague to Lyon?
According to Busbud traveler reviews, the most timely bus company on this route is RegioJet, with a punctuality rating of 4.1 out of 5 stars.
Which bus company has the cleanest buses from Prague to Lyon?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Lyon was searched and found on Aug 27, 2026 with a price of MAD 794To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Lyon, as early as possible.
You can expect to pay from MAD 794 to MAD 1,850 for a bus ticket from Prague to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at MAD 794 which is on 2026-08-27.
Usually BlaBlaCar Bus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
